cogniben reviews
CogniBen is a doctor-formulated natural supplement designed to support the brain’s cognitive functions and increase levels of concentration, energy, and focus.
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In assessing species susceptibility for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and in the search for an appropriate animal model, multiple research groups around the world inoculated a broad range of animal species using various SARS-CoV-2 strains, doses and administration routes. Although in silico analyses based on receptor binding and diverse in vitro cell cultures were valuable, exact prediction of species susceptibility based on these tools proved challenging. Here, we assessed whether precision-cut lung slices (PCLS) could facilitate the selection of animal models, thereby reducing animal experimentation. Pig, hamster and cat PCLS were incubated with SARS-CoV-2 and virus replication was followed over time. Virus replicated efficiently in PCLS from hamsters and cats, while no evidence of replication was obtained for pig PCLS. These data corroborate the findings of many research groups that have investigated the susceptibility of hamsters, pigs and cats towards infection with SARS-CoV-2. Our findings suggest that PCLS can be used as convenient tool for the screening of different animal species for sensitivity to newly emerged viruses. To validate our results obtained in PCLS, we employed the hamster model. Hamsters were inoculated with SARS-CoV-2 via the intranasal route. Susceptibility to infection was evaluated by body weight loss, viral loads in oropharyngeal swabs and respiratory tissues and lung pathology. The broadly used hamster model was further refined by including activity tracking of the hamsters by an activity wheel as a very robust and sensitive parameter for clinical health. In addition, to facilitate the quantification of pathology in the lungs, we devised a semi-quantitative scoring system for evaluating the degree of histological changes in the lungs. The inclusion of these additional parameters refined and enriched the hamster model, allowing for the generation of more data from a single experiment.
ADHD-Relevant Motor and Cognitive Effects of a Fixed-Dose Combination of Caffeine, Gingko Biloba and β-Phenethylamine (PEA)
Background: The aim of the study was to evaluate Cogniben, a fixed-dose combination of caffeine, Ginkgo-biloba and β-Phenylethylamine (PEA) as a potential therapeutic option for attention deficit hyperactivity disorder. Methods: Cogniben-treated mice were tested with the open-field test, object-recognition test, passive avoidance test and activity wheel test. In vitro, the effect of Cogniben and its constituents on release of NO from cultured murine macrophages was assessed. Finally, patients with ADHD were treated with Cogniben and the effect on ADHD Rating Scale-IV and clinical global impression was evaluated. Results: Cogniben exhibited stimulant-like activity, as exhibited by both the open-field test and the activity wheel test. Treatment with Cogniben had positive effects of reducing anxiety and enhancing learning and memory in mice. In-vitro, the Cogniben combination reduced LPS-induced NO release from macrophages, to a similar extent to that of Dexamethazone. In the clinical evaluation, a 43% change from baseline was observed in the ADHD-RS-IV and a 34% reduction in severity from baseline was observed in the CGI-S following treatment with Cogniben. Conclusion: Together, the beneficial effects of the Cogniben combination, suggest that it may be a valuable treatment for ADHD.
The study 1 , published in the August 2015 edition of the Journal of Attention Disorders, looked at 75 healthy teenage boys — without ADHD diagnoses — who were randomly assigned to one of three groups: one taking 250 mg. of Cognizin, one taking 500 mg. of Cognizin, and one receiving a placebo. Each group took the supplement once a day for 28 days. Progress was measured using the Ruff 2&7 Selective Attention Test, Finger Tap Test, and the Computerized Performance Test, Second Edition (CPT-II). After the 28-day trial, boys in both the 250 mg. and the 500 mg. Cognizin groups showed significant improvement in every aspect of these tests, compared to boys who took the placebo.
Dietary Supplement May Improve Attention in Adolescent Males
Taking Cognizin showed positive results on attention, focus, and motor control in teenage boys.
Verified Updated on March 1, 2018
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A double-blind, placebo-controlled study on the dietary supplement Cognizin showed significant gains in psychomotor speed, attention skills, and impulse control in adolescent boys.
The study 1 , published in the August 2015 edition of the Journal of Attention Disorders, looked at 75 healthy teenage boys — without ADHD diagnoses — who were randomly assigned to one of three groups: one taking 250 mg. of Cognizin, one taking 500 mg. of Cognizin, and one receiving a placebo. Each group took the supplement once a day for 28 days. Progress was measured using the Ruff 2&7 Selective Attention Test, Finger Tap Test, and the Computerized Performance Test, Second Edition (CPT-II). After the 28-day trial, boys in both the 250 mg. and the 500 mg. Cognizin groups showed significant improvement in every aspect of these tests, compared to boys who took the placebo.
Cognizin is the brand name for citicoline, a naturally produced substance found in the mitochondria of human cells. The Cognizin supplement, which contains either 250 or 500 mg. of citicoline, is vegetarian and allergen-free, according to the manufacturers. After ingestion of the Cognizin oral supplement, the citicoline is broken down in the intestinal tract into choline and uridine. These molecules travel through the bloodstream to the brain, and — upon crossing the blood-brain barrier — reunite as citicoline, strengthening brain tissue and enhancing neuron pathways. Although dopamine levels weren’t measured in this particular study, prior studies show that Cognizin increases dopamine levels, providing a possible explanation for its positive effects on attention.
Side effects in the study were minimal, and appeared to be the same for both the Cognizin and the placebo groups. Prior studies on Cognizin citicoline were mostly conducted on adults, so its effects on children and teens — whose frontal lobes are still developing — were unknown. Researchers are encouraged by the strong results in this study.
“This is the first study of its kind,” “We’re pleased with the findings that indicate daily supplementation with Cognizin citicoline enhanced attentional processes in healthy adolescent males.”
“Natural supplementation is key,” she said. “Especially during adolescence, when the brain’s frontal lobe is still in development.”
Manufacturers of dietary supplements, like Cognizin, aren’t required to obtain FDA approval before selling their products. None of Cognizin’s statements has been evaluated by the FDA. It remains unclear at this point if Cognizin will have different results, or any additional effect, on children or adults with diagnosed ADHD. Further research is needed to explore Cognizin’s effects on those with abnormal levels of dopamine or underdeveloped frontal lobes.
1 McGlade, E., et al. “The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males.” Journal of Attention Disorders, 2015, doi:10.1177/1087054715593633.
There is significant clinical backing which links black seed oils to healthy anti-inflammatory responses, Zelkha says. “Due to these anti-inflammatory and antioxidant properties, the oil has many potential health benefits including cardiovascular health, respiratory and arthritis health, blood-sugar benefits and much more.”
TriNutra innovates breeding black cumin seeds to tackle inflammatory diseases
07 May 2019 — Israel-based TriNutra has developed the first cold-pressed Nigella sativa oil – black cumin seed – standardized to 3 percent thymoquinone, its main active phytochemical compound. ThymoQuin 3% has anti-inflammatory and antioxidant properties which may promote cardiovascular and respiratory health and regulate blood-sugar levels, Morris Zelkha, CEO of TriNutra tells NutritionInsight. The company, which specializes in the R&D of natural nutritional supplements, spent several years developing a Nigella sativa breeding program to yield a high-concentration of thymoquinone varieties with up to five times more thymoquinone content.
Zelkha says that TriNutra was formed with a vision to serve unmet health needs with formulations that possess immediacy and efficacy. The company has created an innovative approach to product development, focusing on synergistic relationships between ingredients, proper therapeutic dosages and extensive clinical research.
Thymoquinone health benefits
The company employs the cold-pressed method in order to preserve the benefits of the compounds included in the raw materials. The cold-pressed process of oil extraction utilizes only pressure, meaning no heat is added to the paste to promote oil removal. Cold pressing can often produce a lower-yield, but higher quality oil.
Black cumin seed flowers “Our studies have shown that black cumin seed oil standardized to three percent, with a lower free fatty acid concentration, results in improved benefits compared to other black cumin seed oils with lower thymoquinone concentrations and high free fatty acid,” he explains.
There is significant clinical backing which links black seed oils to healthy anti-inflammatory responses, Zelkha says. “Due to these anti-inflammatory and antioxidant properties, the oil has many potential health benefits including cardiovascular health, respiratory and arthritis health, blood-sugar benefits and much more.”
TriNutra is focusing its clinical trials using its standardized oil, ThymoQuin 3%, to see how it may affect different health conditions. For instance, a new animal study, published in the Journal of Nutrition & Food Sciences, showed ThymoQuin’s 3% potential benefits to aid in metabolic function and fatty liver disease.
Innovative aspect
Zelkha notes that TriNutra seeks out recognized ingredients, some that have been around for thousands of years and brings consumers new and improved ways to use them.
“Another unique aspect to ThymoQuin 3% is the synergistic effects it has with other natural ingredients that are not observed with other, less potent black cumin seed oil products. For example, when ThymoQuin 3% is combined with small amounts of omega 3, it demonstrates a significant increase in the omega 3's ability to promote healthy inflammatory responses when compared to omega 3 by itself. We are continuing to study the synergistic effects of ThymoQuin 3% on other ingredients like hemp, astaxanthin, lutein and other carotenes,” he says.
Challenges in formulation and sustainability
In order to achieve its goals of a highly potent black cumin seed oil, TriNutra could not rely on existing varieties and needed to develop its own unique breeding program that would yield a high-concentration of thymoquinone.
Morris Zelkha, CEO of TriNutra “This took several years to accomplish, but our Nigella sativa varieties contain up to five times more thymoquinone than many common varieties. We also spent five years developing our proprietary cold-press technology. Typically, when extracting the oil with heat, it is possible to lose some of its potency from the extraction process. Our method optimizes the extraction to maximize the thymoquinone recovery for a more potent product,” Zelkha explains.
In terms of sustainability, TriNutra’s Nigella sativa plants are grown in controlled, non-GMO conditions. TriNutra believes in having complete farm-to-finished-product traceability, including understanding the history of the farm, the varieties produced, cultivation and harvesting conditions, seed storage as well as processing.
Going forward the company plans to continue to perform clinical studies to better understand the impact that ThymoQuin 3% can have for a wide range of health concerns.
“At TriNutra, we currently have our black cumin seed oil and Cogniben, our cognitive support supplement. Through our research, we hope to incorporate ThymoQuin 3% into additional products and to continue developing and researching its synergistic effects,” Zelkha concludes.
Exceeding the recommended dosage might result in adverse effects. For instance, taking too much vitamin A can cause liver problems.
7 Health Supplement Buying Errors to Avoid Online for New Users
Being health-conscious is commendable, and health supplements are a great way to achieve optimal health. It’s not surprising that many people buy their health supplements online, given the convenience of shopping on the go from anywhere at any time.
Unsurprisingly, this also attracts unscrupulous players who take advantage of consumers by selling fake products or providing misleading product information. So, if you’re a health supplement newbie, be on the lookout for these seven health supplement buying errors:
1. Buying Supplements That Are Not FDA Approved
Always check if health supplements are FDA approved before buying them. This is to ensure you’re getting a genuine product that is safe for consumption. The health supplement industry in the United States isn’t as heavily regulated as pharmaceuticals and drugs, so it pays to be extra vigilant when buying health supplements online or offline.
To add to that, some of these health supplements may contain ingredients that aren’t listed on the label (or have more than what’s stated). These ingredients can be harmful if consumed by children or those who are allergic to certain substances.
Before purchasing health supplements, always check for the FDA disclaimer and seal. Health supplements that are not approved by the FDA may cause health problems.
Some health supplement ingredients might also interact with your existing medications. It’s best to consult your doctor first before buying health supplements online.
2. Not Having a Clear Understanding of What Supplements You Need
Health supplements are supposed to supplement your diet, not replace it. Before buying health supplements online or offline, you should have a clear understanding of what you need and why.
For example, if you’re looking to boost your immune system, vitamin C might be a good option. If you’re looking to improve your skin or hair health, look out for biotin supplements.
But don’t just start taking health supplements without first knowing how they’ll benefit your body—that’s when problems will occur.
Learn more about deer antler velvet, for example, to see what impact it could have.
3. Not Checking the Dosage
Just because a supplement is natural doesn’t mean that you can take more of it. In fact, many health supplement options have dosage instructions listed on the label for a reason.
Exceeding the recommended dosage might result in adverse effects. For instance, taking too much vitamin A can cause liver problems.
Before buying any health supplement, make sure to read and understand the dosage instructions. If you’re still unsure about how much to take, consult your doctor or pharmacist.
Health supplements come in different shapes and sizes—and so do their dosages.
Some people also tend to forget that not all health supplements are meant for daily use. For instance, you should only take probiotics when needed and not on a daily basis.
And don’t double up thinking that it will increase the effects—it doesn’t work like this. Stick to the recommended dosage instructions whenever possible.
4. Not Checking Who Runs the Site
There are a lot of online supplement stores that don’t have your best interests at heart. Some of these sites are operated by fly-by-night operators who care nothing about the product quality or your safety.
Before buying health supplements online, always check who is running the site.
Do they have an established presence online? Are they selling other products as well? What are people saying about their products and services?
If you can’t find information about the company online, it’s probably best to stay away from them. There are plenty of reputable online supplement stores out there that sell high-quality products.
It’s also important to note that not all online reviews are genuine. Some unscrupulous companies might try to generate positive reviews for their products. So, be sure to do your own research before buying health supplements online.
But that doesn’t mean you should ignore online reviews altogether. Online customer reviews can be a great way to get an idea of the quality and effectiveness of a product.
5. Chasing the Latest Headline
There’s a reason why health supplements have been around for centuries—they work. But that doesn’t mean you should buy the latest and greatest health supplement just because you saw it on the news or online.
In fact, many of these so-called “miracle” supplements have yet to be tested or proven effective. Before buying any health supplement, do your research first and see if there is any scientific evidence to support its claims.
Most headlines are designed to get you excited and interested in a product—not because it’s actually good for your health. So, be wary of any health supplement that’s being heavily marketed online.
If it sounds too good to be true, it probably is.
6. Not Knowing the Side Effects
Just because a health supplement is natural, doesn’t mean that it’s safe. Many of these supplements can have serious side effects if used incorrectly or for prolonged periods of time.
If you’re taking multiple supplements at once, there could be potential drug interactions too. Before buying any online supplement, make sure to check its ingredients and possible side effects.
Always read the label before using any health supplement and follow the instructions carefully to avoid adverse reactions or other complications. For instance, some dietary fiber products may cause gas in certain people, so be careful when taking them.
7. Not Comparing Supplement Prices
Health supplements can be expensive, but that doesn’t mean you have to break the bank in order to get good quality products. In fact, there are a lot of online stores that sell high-quality supplements at a fraction of the price.
Before buying any health supplement, always compare prices between different stores. This will help you get the best possible deal on the product.
When comparing prices, make sure to look at the total cost of ownership including shipping and handling charges. Some stores may seem cheaper upfront, but their shipping rates are through the roof.
Health Supplement Buying Errors to Avoid
When buying supplements online, be sure to avoid these health supplement buying errors. By following these tips, you can ensure that you’re getting the best possible products at the best possible price.
If you’re looking for more information on health supplements, be sure to check out the other articles on our website.