Osteo Bi-Flex Cream Reviews

Osteo Bi-Flex Review: Does It Really Work?

Osteo Bi-Flex is a is a joint health supplement that helps the body to deal with joint pain, arthritis, and other related problems by promoting joint fluidity and flexibility.

(Last Updated on March 4, 2022)

The Osteo Bi-Flex line is a suite of joint care supplements.

Osteo Bi-Flex Ease – in particular – is a shellfish-free formula designed to promote and enhance joint comfort.

Just one easy-to-swallow mini-tab a day nourishes your body with herbal and natural ingredients.

Or so that’s the claim.

But does the Osteo Bi-Flex proprietary formula really reduce joint pain?

Keep reading to find out

Supplements that are composed of only MSM have been known to have side effects, including upset stomach and diarrhea. Also, it should not be taken with blood thinners. Discuss this with your healthcare provider as the amount of MSM found in a particular Osteo Bi-Flex product might not be right for you.


Osteo Bi-Flex offers a variety of formulations that contain multiple ingredients; each is a little different. However, there are a few compounds that the brand promotes as the key ingredients. Among these are “Joint Shield,” UC-II collagen, glucosamine, chondroitin sulfate, and methylsulfonylmethane (MSM).

Joint Shield

Osteo Bi-Flex promotes “Joint Shield” as its main ingredient, a proprietary blend of compounds that includes 5-Loxin Advanced—Boswellia serrata extract enriched with a compound known as 3-O-acetyl-11-keto-beta-boswellic acid (AKBA).

5-Loxin is reported to be beneficial for treating osteoarthritis of the knee. In one study, it reduced pain and improved physical function in osteoarthritis patients by controlling inflammation. Though researchers say it is safe, they err on the side of caution, saying that it may improve joint health.

“Joint Shield” is found in most Osteo Bi-Flex products, though they differ slightly in the secondary ingredients. Each of these also has been reported to have some positive effects on osteoarthritis symptoms to varying degrees.


Along with chondroitin, glucosamine has long been recommended as a treatment for osteoarthritis. Its actual effectiveness is under debate and can vary from one supplement manufacturer to another.

Glucosamine is a natural compound found in human cartilage that is responsible for fluid surrounding the joints. In supplements glucosamine is either lab-generated or derived from shellfish shells. For people who have shellfish allergies, glucosamine could be problematic. It’s important to read labels carefully if this is a concern for you.


Another natural compound found in the cartilage, chondroitin, helps retain water in joints. In supplements, the most common source of chondroitin is animal cartilage.

Research into the effectiveness of glucosamine and chondroitin varies greatly. Studies and trials from supplement manufacturers show positive results in its effectiveness in osteoarthritis relief. However, trials by independent organizations have found little to no benefit.

UC-II Collagen

This is undenatured type II collagen that has been known to support joint health. It is included in several Osteo Bi-Flex products. In supplements, it is most often derived from chicken sternum cartilage. UC-II collagen has shown positive results in independent studies of osteoarthritis treatment.

A study tested the effects of UC-II collagen in patients with moderate-to-severe osteoarthritis of the knee and found that patients who took UC-II collagen reported a significant improvement in physical function, stiffness, and pain compared with patients who were given placebo or a combination of glucosamine hydrochloride and chondroitin sulfate.

Methylsulfonylmethane (MSM) is often sold alone as a dietary supplement for different health conditions, including osteoarthritis. Some Osteo Bi-Flex products contain it and typically say “with MSM” on the package.

MSM is a compound that contains sulfur, which is required by the body’s connective tissues. It is thought to fight inflammation, though one study found the benefits to be minimal. It also notes that the clinical significance of MSM and osteoarthritis is unknown.

Supplements that are composed of only MSM have been known to have side effects, including upset stomach and diarrhea. Also, it should not be taken with blood thinners. Discuss this with your healthcare provider as the amount of MSM found in a particular Osteo Bi-Flex product might not be right for you.

What is Osteo Bi-Flex?

Osteo Bi Flex is a line of joint health supplements designed to promote and enhance joint comfort and reduce inflammation.

Osteo Bi Flex is a supplement that has been around for decades with an impressive track record. It was originally developed to help people who were experiencing joint pain and discomfort. Osteo Bi Flex is full of natural ingredients, with most coming from plants or animals sources.

This Osteo Bi Flex review will explore the truth about this product, including what it does and how to take it correctly so you can get the best possible results.

Osteo Bi Flex contains Glucosamine, chondroitin sulfate, manganese ascorbate, magnesium oxide, and vitamin D3. It also comes in chewable tablets that taste great. Osteo Bi Flex is designed for seniors with bone or joint problems because it helps keep these parts of the body strong by providing essential nutrients for healthy cartilage.

The supplement is created by Nature’s Bounty Co . The people behind this brand are committed to providing all-natural medicine, high-quality products for those who suffer from chronic pain and want an effective alternative treatment option, not just pharmaceuticals.

Osteo Bi Flex Products

The company manufacture different products to reduce the pain and inflammation associated with arthritis, back, and knee pain. Some of the supplements are oral while others are topical ointments. Let’s have a quick look at the product list.

  • Osteo Bi-Flex One Per Day: This product contains Glucosamine, vitamin D, and Joint Shield proprietary blend. This supplement is specially designed to nourish damaged joints.
  • Osteo Bi-Flex Triple Action: This formula is made with Glucosamine, manganese, vitamin C, and a proprietary blend of joint health ingredients.
  • Osteo Bi-Flex Ease 7 Day Starter Pack: This is a week-long trial. Osteo Bi Flex’s patented Joint Shield formula can deliver joint comfort within seven days. With this kit, you’ll ensure the product works for your needs and provides optimum results with minimal risks.
  • Osteo Bi-Flex Pain Relieving Cream: This cream is designed for the relief of immediate joint pain. This formula is also packed with Methyl Salicylate, menthol, and Glucosamine.

How Does It Work?

There’s nothing like a good range of motion and healthy knees. Osteo Bi-Flex might be your new secret weapon against joint pain and stiffness associated with osteoarthritis.

The supplement is loaded with 1,500 mg of Glucosamine HCI plus 1,200 mg of Chondroitin Sulfate along with vitamin D. Still, the main ingredient is a proprietary blend called Joint Shield along with Methylsulfonylmethane (MSM), which contains an herbal extract – 5 Loxin. This blend may help reduce pain and improve joint mobility in people with osteoarthritis in the knee and other joints like those on our fingers or hips.

The vitamin D and other ingredients work synergistically to improve your joint health and reduce the pain associated with arthritis or other joint issues.

Benefits Of Using Osteo Bi Flex

According to the manufacturer, the product will help you in the following ways.

  • It will help you revitalize your bone health.
  • Osteo Bi Flex will strengthen your bones with vitamin D.
  • It will also improve your cartilage health.

Osteo Bi Flex Ingredients

If you want to relieve your back pain, then Osteo Bi-Flex Triple Strength can help. The ingredients are supported by research and have been beneficial when combined with other lifestyle factors for optimal results.

  • Glucosamine HCl – 1500mg
  • Joint Shield 5-Loxin Advanced (Boswellia serrata extract) – 100mg
  • Chondroitin/MSM Complex – 1103mg
  • Manganese—2 mg
  • Chondroitin sulfate and MSM complex—1,103 milligrams
  • Collagen
  • Boron
  • Hyaluronic acid

Glucosamine HCl

Glucosamine is an amino sugar. It is a naturally occurring compound and is the building block for developing and maintaining cartilage within your joints [ 1]

Joint health supplements such as glucosamine hydrochloride and sulfate can help support the structural integrity of existing joint cartilage.

In many studies, it appears that one form is more beneficial than another for improving your joints’ discomfort levels- but there’s not enough evidence to determine which works best.

Glucosamine hydrochloride can help improve joint pain. However, it is less effective than the sulfate version of this substance and has been more helpful with discomfort at earlier stages.

This product contains 1500mg of Glucosamine, and the usual recommended dose is also 1500mg per day in a divided dose; you can take it once or in divided doses.

Joint Shield 5-Loxin Advanced Boswellia Serrata Extract (Resin)

Boswellia or Indian frankincense is a natural ingredient obtained from the resin of trees primarily found in India. Since ancient times this ingredient has been used as an anti-inflammatory and may relieve joint pain for those who suffer from it.

With Boswellia serrata extract, many people’s joint health improved within 28 days.

The results of several human studies suggest that study subjects’ joint health improved (within 28 days) when given 100mg per day. Thus, the high-quality extract from Boswellia serrata we get with Osteo Bi-Flex is more than enough to produce significant benefits and can even help alleviate chronic pain.

However, studies are limited in their findings but demonstrate short-term relief, which means we can still enjoy our life while taking these supplements.

So, it may relieve joint pain and discomfort in some people who suffer from these conditions—though more research is needed.

Chondroitin and MSM complex—1,103 milligrams

Osteo Bi-Flex Triple Strength contains a unique chondroitin/ MSM complex, which is effective at reducing joint pain in combination with Glucosamine and other nutrients.

Like Glucosamine and many other supplements, Chondroitin is a popular choice for those suffering from joint pain.

Studies have found that it can relieve such discomfort to some degree. Still, not everyone experiences relief with this treatment alone, so you need to look no further than Osteo Bi-Flex, which includes chondroitin among its ingredients list at full potency.

So another ingredient in this complex is MSM, an organic compound that occurs naturally in the human body and has been found effective at reducing joint pain. The chondroitin/MSM complex in Osteo Bi-Flex Triple Strength also contains collagen, Boron, hyaluronic acid, and additional Boswellia extract for better results.

Collagen and Boron

Collagen and Boron present in Osteo Bi-Flex are both essential for bone growth. Collagen also acts as connective tissue, as our skin does — it holds everything together!

Collagen is a protein that contributes to your rigid bone structures like your skeleton and teeth. The elasticity of your skin is also because of collagen. It’s responsible for all the connective things that hold your cells together, and it’s a significant part of blood vessels, organs, and muscles.

Your body can naturally produce collagen at a slow rate as you age – even slowly after reaching adulthood – but not quite as fast as it breaks down. Because of this, collagen supplements help maintain healthy bones and joints as well as vibrant skin.

While Boron is a chemical element and is found in mineral deposits on Earth all over the world. It’s almost always combined with other elements to form borates. Borates are used industrially in things like fiberglass or ceramics, but they’re also found in many foods you eat.

For example, some plants have boron-containing chemicals called boric acids that are important for building cell walls. A single apple can contain up to 3mg of Boron. Drinking coffee or eating nuts every day could give you up to 3mg of Boron each day.

Hyaluronic Acid

Hyaluronic acid is a substance that naturally exists in the human body. It’s found at high concentrations within joints and eyes, where it can be extracted from rooster combs or made by bacteria laboratory-based techniques for use as medicine today.

A study found that supplementing with hyaluronic acid reduced joint pain in arthritis or other types of joint pain sufferers.

Is It Safe To Use—Osteo Bi Flex Side Effects?

Although the product is tolerated well and the chances of side effects are low.

But this supplement contains Glucosamine, which is derived from shellfish ingredients. People who have a seafood allergy should avoid it due to the risks of an allergic reaction, including eczema and asthma in sensitive individuals.

Here is a list of some common Osteo Bi-Flex Side Effects;

  • The product can cause gastric, stomach upset, and bloating
  • It may also cause nausea and constipation.
  • Hair loss can also be a side effect associated with the use of this supplement.
  • Inflammed or bloated eyelids can also occur.

To avoid these adverse events, it’s better to take them in divided doses. Always consult your doctor if you are already using other medications and supplements.

Ask your healthcare provider if you are pregnant or breastfeeding because some ingredients may not be safe for the fetus or feeding babies.

Is Osteo Bi-Flex A Scam?

The short answer is “definitely not.”

There are many positive Osteo Bi Flex reviews on Amazon and other sites that attest to its effectiveness. Joint Shield is a product that the medical community has backed. Its popularity and usefulness are such that it can be found in professional settings.

While there is not yet much scientific evidence available for UC-II supplementation, the benefits people report from using this product seem very real. With ingredients like Glucosamine, chondroitin sulfate as well, it seems highly likely your joints will thank you soon enough if they suffer from discomfort or pain— so this is definitely not a scam product.

Osteo Bi Flex Dosage—How To Take It?

To avoid stomach upset, you will need to take one pill of Osteo Bi-Flex, preferably with food.

Triple Action MSM formula is a powerful, natural supplement that can be used to help relieve joint pain and discomfort. The recommended dose for this product is two tablets per day – one with dinner time (or at least close enough).

Additionally, there’s an accompanying Pain Relieving Cream you’ll want to apply up 3-4 times daily, which should work great.

You may consider consulting a practitioner who is trained in the use of herbal/health supplements.

If you choose to use Osteo Bi-Flex, be sure to follow package directions for usage and don’t exceed recommendations on labels if using different formulations together because it increases the risk of overdosage.

Cost and Where To Buy Osteo Bi Flex?

The cost is determined by how many items you want to order, what product choices are available on Amazon, and if you’re an Amazon Prime member. Here is what it looks like;

  • The price of Osteo Bi-Flex 1 per day – 30 tablets for $9.50-$9.99
  • The cost of Triple Strength MSM containing 80 pills for $19.57 for a one-time purchase.
  • The cost of Ease Osteo Bi-Flex triple action – 28 mini-tablets for $27.92.
  • The cost of a Pain Relieving Cream for 2.5 ounces is $5.59.

The best place to buy Osteo Bi-Flex is the official company site, Amazon, because of free shipping and many other things. However, the product may also be available in different online and offline pharmacies.

Osteo Bi-Flex Alternatives

Many products are available for the relief of pain associated with the joint and arthritis. Some of them work, while others only rely on tricking consumers. Here is a list of some well-known Osteo Bi-Flex alternatives.

  • Performance Lab Flex —Best For Joint Flexibility Comfort and Overall health. —Pain & Inflammation associated with aging and exercise —Inflammation and back pain
  • Arthrozen—Arthritis supplement

Positive Osteo Bi Flex Reviews

  • Osteo Bi-Flex, One per day, has a 4.5/5 star rating when the total reviews were more than 6000.
  • Most people have praised the product’s efficacy, and for them, it is convenient and easy to take, but the pills are large.
  • For others, it works great for the discomfort associated with the knee and other joints.
  • Some people think it is worth every penny.
  • The customer ratings for Osteo Bi-Flex Ease were 4.6/5 when the total reviews were more than 1400.
  • The Osteo Bi-Flex triple-action Reviews are great, and like the Ease, this product also has impressive ratings, and the total number of people who reviewed this product is more than 7500.
  • Most of the people who already used the formula think it is a miracle in the bottle.

Negative Osteo Bi Flex Reviews

  • Some people who criticized the product were not happy with the size of the pill. They think it is too big to swallow.
  • Others think they got severe allergic reactions after using this supplement—so don’t use it if you are allergic to shellfish.
  • While according to others, the product caused severe burning pain in the stomach.

Osteo Bi-Flex Review: Don’t Buy Before You Read This!

What is it?

Osteo Bi-Flex is a joint health pill brand that claims it can boost the overall function of joints. They make a total of 9 different products in different strengths and each with slightly unique features.

This includes a triple strength, one a day, vitamin D, MSM version and much more. They claim that it’s a pharmacist recommended brand for treating but not curing joint pain. Depending on the product, results can come in quickly as 7 days. Our review experts have analyzed many joint health supplements and they’ve found the best overall is Flexitrinol. It’s a fast acting joint health product that customers and our review experts alike have found great benefits in. Learn more about the benefits of Flexitrinol by clicking the link here.

Osteo Bi-Flex Ingredients and Side Effects

Here are common ingredients added to their brands:

Chondroitin Sulfate Methylsulfonylmethane Collagen Boron Boswellia Serrata
Hyaluronic Acid Manganese Sulfate Vitamin C Glucosamine HCI Natural Palm Leaf Glaze

Chondroitin Sulfate: Chemical extract found in cartilage. It’s used to reduce the breakdown of cartilage which can keep joints working strong. Osteo Bi-Flex’s maximum strength only has a total of 225 mg per serving on their maximum strength, which is lower than other brands.

Methylsulfonylmethane: Extract taken from animals and green plants. It’s been used effectively for reducing joint inflammation and chronic pain.

Boron: Mineral extract that is used to improve bone and mental health. In amounts added to most supplements it has been tested to be safe.

When found in foods and proper dosage strengths via supplements, it can promote the normal growth and overall health of the body.

Boswellia Serrata: Herb used in Ayurvedic medicine to fight inflammation. While studies have shown it to support joint health, Examine.com has added:

“funded by the producers of the tested supplements”

So it’s possible for these clinical studies to be unfairly biased.

Hyaluronic Acid: Found naturally in the body, this helps to lubricate and cushion joints and tissues. Web MD has stated:

“LIKELY SAFE when taken by mouth”

Only in few cases has it shown a possibility for rashes.

Glucosamine HCI: An amino acid sugar that is made in the human body. It provides a cushioning effect on the joints.

Glucosamine HCI is extracted from shellfish and capable of relieving minor pain.

EDITOR’S TIP: Combine this supplement with a proven joint pain pill such as Flexitrinol for better results.

Osteo Bi-Flex Quality of Ingredients

There are many natural ingredients which have been shown to help with joint pain. The issue is that they often don’t add it in high dosage strengths, which makes it weaker than other products.

Even the Osteo Bi-Flex extra strengths products are added in fewer amounts than what other brands offer per serving. For example:

  • Chondroitin: Added in a blend of ingredients and amounting to somewhere around 1,103 mg in their triple strength formula. This makes it likely added in small amounts. A maximum strength version only contains 225 mg per serving.
  • Boswellia Serrata: In the triple strength formula there is only 100 mg per serving, Examin.com mentions that between 800 to 1,200 mg are needed for an average dose.

Due to these lower amounts, it’s possible that even if you were taking the strongest versions of Osteo Bi-Flex products you won’t be receiving ingredients at their most potent.

They do use many good ingredients, but due to the lack of potency it’s not as effective as it could be. Discover which joint health supplements were rated as the best overall by clicking this link.

Drugs.com has also looked at these brands and concluded:

“Stop using… if you have irregular heartbeats; or swelling in your legs”

They also mention that common side effects can include:

  • Nausea, stomach pain, and hair loss.
  • Puffy eyelids, bloating, and gas.
  • Constipation and diarrhea.

There is a possibility for many different side effects, some of which require you to stop taking them immediately.

Those with the following conditions are advised to seek the recommendation of a healthcare professional before taking:

  • High blood pressure, high cholesterol, and diabetes.
  • Asthma, an allergy to shellfish, and bleeding disorders.

This makes it important to proceed with caution before considering Osteo Bi-Flex.

The Price and Quality of Osteo Bi-Flex

Purchases can be made from many online retailers and places where supplements are sold.

Prices can also vary depending on which specific brand is chosen. Here are the prices to each brand currently on Amazon.com:

  • Triple strength 120 tablets: $18.04 for a 60 day supply.
  • Advanced MSM 120 caplets: $6.97 for a 30 day supply.
  • One a day 60 tablets: $18.10 for a 60 day supply.
  • Herbal formula 80 capsules: $6.98 for a 40 day supply.
  • Joint and Bone 74 tablets: $24.00 for a 37 day supply.
  • Ease 28 tablets: $17.08 for a 28 day supply.

The main issue with these brands is that even the strongest one isn’t as potent as the best joint health supplements. There is also a possibility for side effects and people with certain health conditions are not advised to supplement.

A claim is made that people often see results within 7 days of use. In reading the fine print it’s revealed that this is for one sole ingredient called 5-Loxin, which is a patented version of boswellia serrata extract.

This study was flawed however as it was funded by the manufacturers of this patent which could be potentially biased.

Yes another issue is that while boswellia serrata has been shown to be effective, Osteo Bi-Flex adds it in small amounts. This makes it less likely to have an impact on improving joint health.

Business of Osteo Bi-Flex

The company behind Osteo Bi-Flex is called PL Thomas – Laila Nutra, LLC and their contact information is:

Phone Number: 1-888-848-2335

Address: 2100 Smithtown Avenue

Ronkonkoma, New York 11779

A contact form is also listed on their official website for direct messages.

They specialize in herbal nutraceuticals and they’re made up of a combination of 2 major businesses that recently joined together.

No information exists on whether or not they offer a money back return policy, so it’s unlikely they offer returns. No other information is listed on any websites such as the Better Business Bureau, so it’s unknown how they handle customer concerns.

Typically a company this large should have some sort of customer feedback, so it’s likely they have not had any serious issues.

Customer Opinions of Osteo Bi-Flex

Here are some select reviews taken from users:

“started to experience GERD flare-ups and once I stopped taking it my esophageal burning disappeared”

“it improved my arthritic problems in my hands but it takes some time to work”

“didn’t really work that well, still experiencing elbow and knee pain”

“started feeling rising headaches especially near the back of my head and neck”

There were mixed reviews from people who either experienced no change, some benefits, great benefits, and or side effects. The kinds of side effects experienced included:

  • Headaches, nausea, and stomach pain.
  • Difficulty eating, throat discomfort, and burning in the throat.
  • Diarrhea, indigestion, and feeling of fullness.

Those that did have negative experiences mention they felt normal as soon as they stopped taking their chosen version.

No matter which brand was reviewed, each one had the same kinds of issues and effects according to users. This is likely since the formulas are essentially the same with minor additions and different dosage strengths.

How Does Osteo Bi-Flex Compare?
  • Product Name
  • User Rating
  • Good Company Reputation
  • Quality Ingredients
  • Money Back Guarantee
  • Flexitrinol
    (Editor’s Choice)
  • 97/100
Conclusion – Does Osteo Bi-Flex Work?

Osteo Bi-Flex makes a wide assortment of joint health products in varying strengths and with slightly different ingredients. While this provides variety, they often fail to add significant amounts of key ingredients such as chondroitin and boswelia serrata. This makes it unlikely to work as effectively as other joint health supplements. There were also mixed reviews from people who either did notice a difference, or those who felt it was a waste of money or that it promoted side effects.

There’s also no mention of a money back guarantee which likely makes all sales final. Prices can vary wildly between each specific brand and the manufacturers often fail to add sufficient dosage strengths for most of their products.

By reviewing many joint health supplements our experts have found Flexitrinol was the most effective. It has the right amount of ingredients at dosage strength preferable for reducing joint pain. Many customers have benefited from its potent mixture of ingredients.

Flexitrinol is also manufactured in a GMP certified facility to ensure routine quality and potency. This is a way for 3rd party inspections to ensure that the ingredients are made in a safe and clean facility. It also guarantees that there are strict policies on ensuring routine inspections. Discover more about the benefits of Flexitrinol by visiting the link here.

Verdict—Osteo Bi Flex Review

What have we learned so far from this Osteo Bi Flex Review?

Number one, the product is manufactured by a well-known company with a strong reputation.

The company has several options for joint relief. Still, you may find better joint pain supplements such as Performance Labflex, which work better due to the different combinations and amounts of proven ingredients.

Second, the supplement has some ingredients that will improve your joint pain, but avoid it if you are allergic to any of the constituents in Osteo Bi-Flex.

The product has a seven days sample pack which you can try without any risk.

The main drawback of this product is that the official website does not show any potential side effects or medicine interactions.