femicrine reviews

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NOTICE II

On September 27, 2019, Environmental Research Center filed a Notice of Violation of California Law Proposition 65, against Systemic Formulas, Inc.

In this action, ERC alleges that 16 specific products manufactured, distributed, or sold by Systemic Formulas, Inc. contain lead, a chemical listed under Proposition 65 as a carcinogen and reproductive toxin, and expose consumers to lead at a level requiring a Proposition 65 warning.

These products are:

Systemic Formulas Femicrine Female Endocrine Support
Systemic Formulas Bio Function F+ Female Plus
Systemic Formulas Bio Function Ga Adrenal
5 Chinese Elements Command General Sedate Invigorate Vitality
Systemic Formulas Bio Nutriment MIN Multi Mineral Plus
Systemic Formulas Bio Function P Pancreas
Systemic Formulas ZGlutn Gluten Control
Systemic Formulas Bio Function Ls Liver S
Systemic Formulas Bio Challenge SENG Lymphogin
Systemic Formulas Bio Challenge VRM2 Small
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5 Chinese Elements Command Energy Sedate Clear Heat
5 Chinese Elements Earth Tonify Warm The Center
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Studies suggest that regular exercise has a profoundly positive impact on microbiome health in a few different ways. Firstly, exercise can enhance the number of beneficial species of microbes in the gut. It also promotes movement within the gut, which supports digestion. Exercise also plays a crucial role in regulating hormones, managing weight, and promoting good mood– all of which are intricately connected to gut health.

Toxins and Hormone Health: The Ultimate Microbiome Destroyers

Toxic exposure has one of the most profoundly negative impacts on your microbiome health. Environmental toxins alter the composition and metabolic activity of the gut microbiome, leaving you with a weaker gut and reduces species of microbes.

Toxins are like a drop of water in a bucket, although many may seem insignificant at the time, the bucket begins to fill up drop by drop. Once the bucket overflows, we begin to see the full range of modern illnesses develop.

Many of the intensely unpleasant symptoms that women experience during perimenopause and menopause are tied to toxicity, and it’s influence on hormonal health. Before assuming “this is just how it is,” consider adopting a toxin-free lifestyle and boosting gut resilience with some of the suggestions below.

For many menopausal women, hot flushes are an uncomfortable inconvenience.

'Game changing' menopause pill cuts hot flushes by three quarters

A “game-changing” wonder drug could reduce hot flushes in menopausal women by up to three quarters, a study by Imperial College Research suggests.

Scientists said the “exciting” findings could offer hope to hundreds of thousands of women who are plagued by symptoms which left many sleep-deprived, anxious and depressed.

Each year around 1.5 million women experience menopausal symptoms, including 400,000 who suffer them to a troublesome extent.

But many shun hormone replacement therapy, because it has been linked with an increased risk of breast cancer and blood clots.

The study published in The Lancet found that a new drug was able to reduec the number of women suffering seven or more hot flushes a day by as much as 73 per cent.

The treatment also reduced their severity and impact, the research found.

Scientists said women taking part in the trial said they felt “human again” after suffering distressing and debilitating symptoms for years.

The average menopause lasts for seven years, and four in five women will suffer hot flushes.

The new drug compound called MLE4901, tested on women who suffered severe flushing, works by targeting receptors in the brain, blocking a chemical called neurokinin B (NKB).

Researchers said it could offer hope to women who were currently enduring misery, but avoiding HRT because it was unsuitable or nor preferred because of safety concerns.

The new study, funded by the Medical Research Council and the National Institute of Health Research involved women with severe flushing, who were given the drug to try to relieve their symptoms.

Author Professor Waljit Dhillo, from the Department of Medicine at Imperial, said: "If a woman is having more than seven flushes a day and the drug is getting rid of three-quarters of them, that’s pretty life-changing.

"For day to day living and work, that’s a significant impact on quality of life. If we can reduce flushing by 73 per cent it’s a game-changer for those patients."

The randomised, double-blind, placebo-controlled trial, involved 28 menopausal women aged between 40 and 62 years old – and who experienced seven or more hot flushes a day and had not had a period in at least 12 months.

Participants were randomly chosen to either first receive a 80 mg daily dose of the drug compound, originally developed by AstraZeneca and licensed to Millendo Therapeutics, or a placebo over the course of four weeks – before switching to receive the other tablet for a month.

The researchers found that the compound MLE4901 significantly reduced the average total number of flushes during the four-week treatment period, as well as their severity, compared to when the patients received the placebo for four weeks.

It also helped to reduce the impact of flushes on the women’s lives, improving sleep, the findings, presented to the annual meeting of the Endocrine Socieyt, in Florida, showed.

Professor Dhillo said: "A lot of women are choosing not to take HRT because it is oestrogen-based. This new drug is a pill which blocks the NK3 receptor, so it won’t have the side effects associated with oestrogen."

He said the findings, from the proof of concept study would now need to be tested over the long term in a larger group of patients.

For many menopausal women, hot flushes are an uncomfortable inconvenience.

But a significant number suffer to such an extent that bed sheets end up drenched in sweat, while relentless insomnia can leave them struggling to cope during the day.

Analysis of brain tissue from post-menopausal women has previously revealed elevated levels of NKB in their brains, while giving the chemical to younger patients has been found to induce flushing.

“It was so exciting to see the lives of those who participated in the study become transformed when their flushes improved once taking the new drug. They could sleep through the night, and be less embarrassed in the daytime; they told me they felt ‘human again’."

Elaine Barker, aged 61, one of the participants in the study, said she enrolled in an attempt to combat daily and nightly hot flushes. “Anything that could improve the quality of my life would be worthwhile,” she said. “When taking the tablets my flushes noticeably reduced and I woke less often at night and my quality of sleep improved.”

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Precautions

Before taking this product, tell your doctor or pharmacist if you are allergic to any of its ingredients; or if you have any other allergies. This product may contain inactive ingredients (such as soy found in some brands), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before taking this medication, tell your doctor or pharmacist your medical history, especially of: iron overload disorder (such as hemochromatosis, hemosiderosis), use/abuse of alcohol, liver problems, stomach/intestinal problems (such as ulcer, colitis).

If your brand of multivitamin also contains folic acid, be sure to tell your doctor or pharmacist if you have vitamin B12 deficiency (pernicious anemia) before taking it. Folic acid may affect certain laboratory tests for vitamin B12 deficiency without treating this anemia. Untreated vitamin B12 deficiency may result in serious nerve problems (such as peripheral neuropathy). Consult your doctor or pharmacist for details.

Tell your doctor if you are pregnant before using this medication.

This medication passes into breast milk. Consult your doctor before breast-feeding.

10 Yang, Chun Z et al. “Most plastic products release estrogenic chemicals: a potential health problem that can be solved.” Environmental health perspectives vol. 119,7 (2011): 989-96. doi:10.1289/ehp.1003220

References

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3 Posted by Christiane Northrup, M.D. “What Are the Symptoms of Estrogen Dominance?” Christiane Northrup, M.D., 14 Mar. 2017, www.drnorthrup.com/estrogen-dominance/.

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7 Lam, and Dorine Lam. Estrogen Dominance: Hormonal Imbalance of the 21st Century. Adrenal Institute Press, 2012.

8 Yang, Chun Z et al. “Most plastic products release estrogenic chemicals: a potential health problem that can be solved.” Environmental health perspectives vol. 119,7 (2011): 989-96. doi:10.1289/ehp.1003220

9 Cao, Jinyan et al. “Soy but not bisphenol A (BPA) or the phytoestrogen genistin alters developmental weight gain and food intake in pregnant rats and their offspring.” Reproductive toxicology (Elmsford, N.Y.) vol. 58 (2015): 282-94. doi:10.1016/j.reprotox.2015.07.077

10 Yang, Chun Z et al. “Most plastic products release estrogenic chemicals: a potential health problem that can be solved.” Environmental health perspectives vol. 119,7 (2011): 989-96. doi:10.1289/ehp.1003220

11 Bergman Jungeström, Malin et al. “Flaxseed and its lignans inhibit estradiol-induced growth, angiogenesis, and secretion of vascular endothelial growth factor in human breast cancer xenografts in vivo.” Clinical cancer research : an official journal of the American Association for Cancer Research vol. 13,3 (2007): 1061-7. doi:10.1158/1078-0432.CCR-06-1651

12 Patisaul, Heather B, and Wendy Jefferson. “The pros and cons of phytoestrogens.” Frontiers in neuroendocrinology vol. 31,4 (2010): 400-19. doi:10.1016/j.yfrne.2010.03.003

13 Gencel, V B et al. “Vascular effects of phytoestrogens and alternative menopausal hormone therapy in cardiovascular disease.” Mini reviews in medicinal chemistry vol. 12,2 (2012): 149-74. doi:10.2174/138955712798995020

14 Wall, Emma H et al. “The role of genetics in estrogen responses: a critical piece of an intricate puzzle.” FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol. 28,12 (2014): 5042-54. doi:10.1096/fj.14-260307

15 “Estrogen Tutorial.” DUTCH Test, dutchtest.com/video/estrogen-tutorial/.

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19 Sitruk-Ware, Regine, and Anita Nath. “Characteristics and Metabolic Effects of Estrogen and Progestins Contained in Oral Contraceptive Pills.” Best Practice & Research Clinical Endocrinology & Metabolism, vol. 27, no. 1, 2013, pp. 13–24., doi:10.1016/j.beem.2012.09.004.

20 Mnif, W., Hassine, A. I., Bouaziz, A., Bartegi, A., Thomas, O., & Roig, B. (2011). Effect of endocrine disruptor pesticides: a review. International journal of environmental research and public health, 8(6), 2265–2303. https://doi.org/10.3390/ijerph8062265

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22 Tsuchiya, Yuki et al. “Cytochrome P450-mediated metabolism of estrogens and its regulation in human.” Cancer letters vol. 227,2 (2005): 115-24. doi:10.1016/j.canlet.2004.10.007

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24 Hechtman, L. (2014). Clinical naturopathic medicine. Sydney, Australia: Churchill Livingstone/Elsevier Australia.

25 Briden, Lara, and Jerilynn C. Prior. Period Repair Manual: Natural Treatment for Better Hormones and Better Periods. Greenpeak Publishing, 2018.

26 Rajaratinam, Harishini, and Siti Norasikin Mohd Nafi. “Andrographolide is an Alternative Treatment to Overcome Resistance in ER-Positive Breast Cancer via Cholesterol Biosynthesis Pathway.” The Malaysian journal of medical sciences : MJMS vol. 26,5 (2019): 6-20. doi:10.21315/mjms2019.26.5.2

27 Baker, J. et al. (2017) Estrogen-gut microbiome axis: Physiological and clinical implications. Maturas, 103, 45-53.

28 Klinder, Annett et al. “Impact of increasing fruit and vegetables and flavonoid intake on the human gut microbiota.” Food & function vol. 7,4 (2016): 1788-96. doi:10.1039/c5fo01096a

29 Veiga, Patrick et al. “Changes of the human gut microbiome induced by a fermented milk product.” Scientific reports vol. 4 6328. 11 Sep. 2014, doi:10.1038/srep06328

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