1. Unpopular Hormonal Therapy and High Diet of Soy in Japan
Hormone Replacement Therapy (HRT) for menopause symptoms is very popular in western countries, including the USA. 38% of American women use hormonal therapy to treat symptoms. More than half of the women in Australia use HRT. But interestingly, in Japan, less than 2% of women use HRT.
Studies reveal multiple reasons why the women in Japan don’t use HRT as much as women in other countries. One of the leading reasons is that Japanese women experience far fewer difficulties concerning menopause than women in North America.
Changes in hormones, specifically estrogen, cause menopausal symptoms. Hormone replacement therapies and supplements try to rebalance the hormones, but not always with success. In Japan, a solution exists. How can so few of the women there need HRT when so many women in other countries do? The secret lies in one ingredient: soy.
This chart shows how daily consumption of soy in Japan is the highest in any country In comparison, American consumption of soy is one of the lowest.
While Americans may simply think of soy as soy sauce, the Japanese have created hundreds of ways to consume soy for each meal. For example, a typical Japanese breakfasts consists of tofu (curd made from mashed soybeans) seasoned with soy sauce, miso soup (fermented soy), and natto (brown beans made from fermented soy).
There are many ways to consume soy. Other soy-based foods in Japan include edamame (green soybeans), Moyashi (white, sprouted soy), Oage (the skin of deep fried tofu), Okara (a by-product of tofu), Nimame (boiled soybean), and Yuba (skimmed, boiled soy milk).
In the late 19th century, Admiral Matthew C. Perry brought soybeans to the US from Japan. Nowadays, soybeans are mainly cultivated for protein-rich animal feed or for their oil.
2. Amazing Power of the Special Isoflavone Contained in Fermented Soy
Soy products contain isoflavones. Miso soup and soy sauce, fermented soy foods, contain a specific isoflavone, aglicone, which works differently than other standard isoflavones.
Some studies show that isoflavone supplements don’t cure or reduce menopause symptoms. In most cases, this has been proven because the standard isoflavone can’t be absorbed by most people. Less than 20% of Americans have the needed enteric bacteria to properly absorb the standard isoflavone and convert it to its usable form: isoflavone aglicone. Isoflavone aglicone works as a stimulator in the body, enhancing the natural DHEA synthesis.
Intriguingly, this particular variation of isoflavone is the compound that is present in miso soup and soy sauce. Therefore, stimulating benefits of the isoflavone aglicone in miso soup and soy sauce can be absorbed by anyone.
BEING IN LOVE MAKES YOU MORE BEAUTIFUL
Yes, it’s true. Love will activate your estrogen synthesis and add to your physical charm. By taking isoflavone aglicone, the same thing happens through your natural function. It won’t stop at menopause relief. It will dial back your physical age. Makeup will sit better, your metabolism will be up and you can lose your weight more efficiently, clouding fatigue will be removed and decreasing desire is reversed.
A huge cohort study, conducted by the National Cancer Center of Japan, followed 20,000 women, ages 44-59, for 10 years. The study aimed to find correlation between soy-based foods and risk of breast cancer.
Charts show an isoflavone-high diet decreases the onset ratio of breast cancer. A diet specifically high in miso soup has the strongest negative correlation with risk of breast cancer.
The reason is now clear: Miso soup contains the isoflavone aglicone, which is easily absorbable and stimulates the body’s natural systems.
(remark: We are simply introducing a study in public, but never be in a position to determine any medical facts.)
Fantastic! Let’s eat miso soup everyday, starting today!
It’s not practical to completely change the diet of someone, especially a North American woman, who isn’t accustomed to the flavor and practice. Ingredients for miso soup aren’t as readily available in the United States, and trying to convince a family to eat miso soup for every meal may be difficult.
But, there’s another way to tap into the secret of Japanese women who have fewer menopausal difficulties
A well-known Japanese food manufacturer, Nichimo Biotics, succeeded in isolating Isoflavone Aglicone from fermented soybean germ with a patented extraction method. This extraction is the exact same isoflavone aglicone as the compound in miso soup.
(Nichimo-Biotics is a subsidiary company of Nichimo, a Japanese food manufacturer with sales of approx. $1 billion and is listed on the 1st section of the Tokyo Stock Exchange. )
3. Activate Your Body’s Natural Adjustment. So Safe, So Effective.
It’s Totally a New Idea, While Already Popular in Japan.
BUT HOW DOES ISOFLAVONE AGLICONE HELP JAPANESE WOMEN?
Isoflavone Aglicone alleviates menopausal symptoms in a natural way, a method different from any other major hormone replacement therapies.
As estrogen decreases with age, menopausal symptoms intensify. Looking for more estrogen, many women turn to hormone replacement therapy or supplements like DHEA. These methods give the body more of what is missing: estrogen. It sounds like a direct solution; perhaps it should work. But the results are revealing.
This typical western “solution” contains various problems. Estrogen exists in a miniscule quantity; each woman has varying levels. Estrogen levels continually shift as well. It is very difficult to maintain a balanced estrogen level by externally supplementing estrogen or phytoestrogen. The dosage may be too little and therefore ineffective, or it may be too high and can cause severe side effects.
For this reason, women seeking HRT need to consult a doctor, but the price of these consultations and remedies adds up. HRT costs includes pills, doctor visits, blood tests and hormone tests, and the client must repeat these tests multiple times.
DHEA, one of the most common estrogen supplements, is a precursor of estrogen. These supplements do work well but American doctors rarely recommend them because, without proper supervision tailored to a woman’s specific estrogen levels, consumption of DHEA supplements can also cause severe side effects.
We wondered why western women take such complicated and risky solutions while there is an easy and safe way in Japan. We found various obstacles. One thing common sense in Japan is not known at all in America. And, most supplement sellers pursue easy sell with well known ingredients and rely heavily on marketing techniques rather than pursuing the real solution for their customers. We thought the honest and amazing work of AglyMax® should be introduced to the world, and women all over the world deserve to know it. Our first motive, and our mission even now, is to link such real solutions made by people who really pursue customer’s benefits, and people who really need them over the distance and over the sea of tons of similar products pursuing quick sell rather than customer’s relief.
The main ingredient of EFFISOY ®, AglyMax® provides the body with estrogen, but in a unique way, based in the science and practice of the Japanese. With age, the natural synthesis of DHEA weakens in the body, which is why women look to supplements. However, EFFISOY ® actually enhances the body’s natural synthesis of DHEA, an estrogen precursor. You don’t need external supplements because your body is rebalancing its hormone levels.
But wait: Is isoflavone a phytoestrogen?
Isoflavone is a very weak phytoestrogen; it has roughly 1/1,000 to 1/10,000 of Estrogen[1] . Doctors note this to be negligible. For example, the study from The National Cancer Center of Japan showed how women who drink more miso soup have fewer tendencies of onset breast cancer. They think it is because such a weak phytoestrogen protects the estrogen receptor from too much stimulation. Western institutions and studies have confirmed this belief that though isoflavone is a phytoestrogen, its strength is negligible[2] .
The average intake of Isoflavone as Isoflavone Aglicone by Japanese is 18-22mg/day. The maximum Japanese health authorities recommend is 75mg/day, which is half of the quantity which is considered to be very safe. (EFFISOY contains 60mg of AlgyMax. 60mg of AglyMax contains 20mg of pure Isoflavone Aglicone per dosage.)
4. Anti-Aging for All Women
EFFISOY helps rebalance your hormones naturally. It works within and with your body, and is a safe and effective solution to menopausal symptoms.
IT IS AS SAFE AS EATING FOOD. UNLIKE HRT AND DHEA SUPPLEMENTS, ANY WOMEN CAN TAKE EFFISOY EVEN WITHOUT HAVING SEVERE MENOPAUSAL SYMPTOMS. PREMENOPAUSAL WOMEN AND THOSE WHO ADDRESS BEAUTY AND HEALTH PROBLEMS WITH AGE CAN ALSO ENJOY THE BENEFITS.
MAKEUP WILL SIT BETTER, YOUR METABOLISM IS REVIVED, YOU CAN LOSE WEIGHT MORE EFFICIENTLY, FATIGUE IS ALLEVIATED, YOUR BONE HEALTH IS BACK AND MORE. ALL LIKE WHEN YOU WERE YOUNGER.
For over a decade, AglyMax was only available in Japan, but we just launched our first line, EFFISOY ® last year. EFFISOY ® is the only supplement containing AglyMax in the USA.
Now you can experience the health benefits of the healthy, soy-based culture of Japan without having to change your diet. EFFISOY ® gives your body all it needs to regulate hormonal imbalances.
Here you can learn how to naturally treat menopause symptoms from Dr.Melissa’s more general view. (This movie is from her YouTube channel, Natural Health Resources.) Diindolylmethane(DIM): There are conflicting claims about the effectiveness of this ingredient; some say it acts like estrogen and stimulate the estrogen receptors, while others claim that it may actually block the effects of the female hormone [3] .
Who Is The Manufacturer Of Effisoy?
Effisoy is carried by the supplement brand Juveriente® and developed by a company called Nichimo, a famous food manufacturer in Japan. Aglymax®, the key ingredient in this supplement, is obtained through the extraction method patented by the company.
Supplements containing Aglymax® are widely popular in Japan as menopause relief solutions prescribed by obstetrician-gynecologists. In other countries, Effisoy is the only brand that features this key ingredient.
Many attempts have been made to identify demographic characteristics associated with a significantly increased risk of hot flushes. For many years, low body mass index (BMI) and race were considered significant predictors of VMS, with thin, white women believed to at the highest risk for hot flushes. More recent findings have suggested that high BMI and African American race are associated with a higher risk of VMS. This shift may be related to better sampling of the general population by major clinical trials because, traditionally, white middle-class women participated in clinical trials that often did not include women from other ethnic groups.
The multiethnic SWAN not only demonstrated a link between an elevated BMI (≥27 kg/m 2 ) and hot flushes [4], but an increased prevalence in African American women, as mentioned. Ongoing studies continue to investigate potential predictors of hot flushes. Smoking, maternal history, history of premenstrual complaints, elevated basal core body temperature, low physical activity, low socioeconomic status, and low levels of estrogen and high levels of luteinizing and follicle-stimulating hormones prior to the menopausal transition have all been associated with an increased risk of hot flushes [4,6-8].
A natural compound from a plant that can act like estrogen in the body is called a phytoestrogen. In spite of their name, phytoestrogens are not actually estrogens but are similar in structure. Due to the recent information about prescription hormone therapy, natural phytoestrogens are very popular and commonly used to combat menopause symptoms such as hot flashes and night sweats.
Soy isoflavones are sometimes referred to as phytoestrogens and have the most potent estrogen-like activity of all common phytoestrogens. Soy beans and other legumes contain isoflavones and are an important source of dietary phytoestrogens. There are many different isoflavones found in plants. The isoflavones with the most estrogen like actions are daidzein, genistein, formononetin and biochanin. They are found in differing amounts in various legumes. Soy contains daidzein, genistein and glycitein. Other legumes, such as chickpeas and red clover, contain formononetin and biochanin.
In its natural form, the soy isoflavones are found attached to a protein. It should be noted that soy protein and soy isoflavones are not the same thing. Foods that contain soy protein can contain isoflavones but the content will vary widely. Depending on the processing involved, the content can vary anywhere from virtually zero to around 2 milligram of isoflavones per gram of protein. Therefore, for optimal benefit of the soy isoflavone, it is important to ascertain the isoflavone content of any particular soy product or food chosen.
Another aspect that is important to isoflavones is the structure that it is in. Isoflavones can only be helpful if they are absorbed by the body. However, isoflavones cannot be absorbed in their natural form, called an ‘isoflavone glycoside’. An ‘isoflavone glycoside’ is the isoflavone attached to a sugar molecule. This sugar molecule must be removed before it can be absorbed by the human gastrointestinal tract. Once the sugar molecule is removed, the isoflavone is referred to as an ‘isoflavone aglycone’. Converting the ‘isoflavone glycoside’ to the ‘isoflavone aglycone’ is accomplished by intestinal enzymes. Importantly, there can be considerable individual variability on how effectively isoflavones can be processed by these enzymes and absorbed.
Certainly, the research surrounding soy has been very encouraging about its potential to deliver many healthful benefits. But too often it is unclear what is being tested since studies have looked at all kinds of soy foods and supplements and there has been no consistency in the products being tested. This may be one of the reasons why soy research does not always produce positive reproducible results. However, most research has consistently identified isoflavones as the key component for soy’s benefits. Regardless of the source, just remember that these compounds must be absorbed in sufficient quantities before they can have any effect in the body.
What are the Uses of Soy?
A number of studies have demonstrated the effectiveness of soy enriched diets on risk factors for breast cancer, cardiovascular disease and osteoporosis, as well as helping to combat some of the unpleasant symptoms of the menopause. Further studies are necessary to evaluate whether these interventions are effective in actually decreasing the incidence of heart disease and osteoporosis associated fractures in postmenopausal women , but the findings so far are very encouraging.
Breast Cancer
Recently in the news, a fermented soy bean paste called miso was linked to a substantial decrease in the risk of breast cancer among Japanese women. This epidemiological study was conducted by researchers at Japan’s National Cancer Center . The researchers monitored the eating habits of 21,852 women ages 40-59 for a period of 10 years starting in 1990, by carefully assessing their diets and lifestyle habits. The research found that women who had three or more bowls of miso soup daily reduced their risk of breast cancer by 40% compared to those who only ate one bowl. Those who had two bowls of miso soup reduced their risk by 26%. The conclusion was that the more miso soup and isoflavones taken daily, the less risk of breast cancer. However, researchers were only able to identify this trend with miso soup consumption and not other soy foods or supplements. Soy foods contain isoflavones, but could not be linked, by themselves, with breast cancer risk reduction.
Miso soup consumption has been the subject of many studies, and has been associated with a reduced risk of certain cancers, heart disease, stroke, and radiation poisoning. While no single dietary factor can be responsible for one’s health, it’s hard to refute that miso soup has been a large contributing factor to Japanese health. The main difference between miso soup and other soy foods consumed by the Japanese is the fermentation process. This fermentation transforms the isoflavones in soy into their active aglycone form which can be used by the body for a host of health concerns, including menopause. In addition, this fermentation process also turns soy into a powerful antioxidant.
Menopause symptoms
Several studies have shown that women who consume large amounts of soy-based phytoestrogens have fewer menopausal complaints. Asian diets typically contain 40 to 80 milligrams of soy isoflavones per day, compared to 3 milligrams per day for American diets. A scientific study of 104 postmenopausal women examined the consumption of 60 grams of isolated soy protein with 60 grams of the common milk protein (casein) per day for 12 weeks. Women receiving the soy experienced a 45% reduction in hot flashes, which was significantly different from the milk protein group. This difference was noted by the fourth week of treatment. Nagata performed a study evaluating soy and hot flashes among Japanese women. They found soy to have a protective effect against hot flashes. 101 women who developed moderate to severe hot flashes over 6 years were studied and found to have less hot flashes with higher soy intake.
Although phytoestrogens are helpful in relieving hot flashes, they may not totally eliminate these symptoms in severe cases. As with all natural approaches, you should also allow sufficient time for the treatment to take effect, generally in the range of 4 to 12 weeks. The addition of estrogen with phytoestrogen use for menopause symptoms has not been conclusively studied.
Bone Health and Osteoporosis
A recent study showed that post-menopausal Japanese women who consumed higher amounts of soy isoflavones had a higher bone density. Somekawa studied 478 postmenopausal Japanese women, and found their average intake of isoflavones to be 54 milligrams per day. They found a higher bone density in the higher isoflavone intake group. Their conclusions were “that high consumption of soy products was associated with increased bone mass in postmenopausal women and might be useful for preventing hypoestrogenic effects.”
Genistein was recently found to reduce bone loss and increase bone density in postmenopausal women in a double blind, placebo controlled study by Morabito and colleagues. This study compared 90 healthy post-menopausal women to receive the phytoestrogen genistein, hormone therapy(HT) or placebo. Measurements were made to determine bone turnover, formation and density at the start of the study and after 6 and 12 months. Results revealed that genistein and HRT both decreased bone turnover and increased bone mineral density over the course of the study. Genistein was well tolerated in this study and was not associated with vaginal bleeding.
A comparison between HT and a soy rich diet was studied by Chiechi with regards to bone turnover and bone mineral density(BMD) in 187 post-menopausal women. The soy rich diet was not as effective as HRT in reducing bone turnover, but did stimulate bone growth. This trial suggested that soy protein may be effective in reducing the risk of osteoporosis in post-menopausal women.
A ten week study of postmenopausal Japanese immigrants in Brazil by Yamori using soy isoflavones was performed to determine the effects on bone metabolism. Bone breakdown markers were significantly reduced in the isoflavone group after 10 weeks, demonstrating that dietary intake of soy may inhibit postmenopausal osteoporosis.
Cardiovascular effects
The FDA has stamped their approval of soy dietary supplementation. They state that 25 grams of soy per day with a prudent diet may reduce the risk of heart disease. The FDA did not make clear whether it was specifically the soy protein, the isoflavones, or a combination of both that is responsible for this benefit.
Researchers have shown major reductions in LDL cholesterol (bad cholesterol) with soy intake. It was reported in a recent Ob/Gyn News and the annual scientific sessions of the American Heart Association that high blood levels of soy phytoestrogen were associated with favorable lipid levels in women with suspected myocardial ischemia. These effects were independent of and additive to the benefits of hormone replacement therapy upon serum lipids. Dr. Bairey Merz studied 239 subjects as part of a subset participating in the Women’s Ischemia Syndrome Evaluation study who underwent coronary angiography for suspected myocardial ischemia. There was apparently a highly significant relationship between soy phytoestrogen and blood levels of lipids. The higher the phytoestrogen level the closer to normal level of LDL cholesterol.
A review of 38 studies on the effects of soy rich diets found an association of reduced total cholesterol (9%), bad (LDL) cholesterol (13%), and triglycerides (11%) with an average intake of 47 grams per day.
Soy phytoestrogen supplementation was found to have a beneficial effect on specific markers in postmenopausal women with diabetes, thus improving their cardiovascular risk profile. Thirty two post-menopausal women with diabetes were studied using a dietary supplement of soy protein compared to placebo over 12 weeks. Results revealed soy phytoestrogens favorably altered insulin levels, sugar control and cholesterol levels which was felt to improve their cardiac risk.
Soy intake resulted in significant reductions in risk factors for osteoporosis and cardiovascular disease in postmenopausal women. Forty two postmenopausal women consumed three servings of soy foods over 12 weeks containing 60 milligrams per day of isoflavones. Results showed that soy intake reduced several clinical risk factors for cardiac disease and osteoporosis.
.
What are the recommended Preparations/ Dosages?
Current recommendations for phytoestrogen intake are as follows:
1) 40 to 160 milligrams of isoflavones per day may be beneficial.
2) 25 grams of soy protein via dietary intake. This equates to approximately 1/2 cup dried soy beans -or- 1 cup tofu -or- 1/3 cup isolated soy protein.
3) Y ou can easily control your isoflavone intake level with Revival Soy. For example, if you want to consume 80 milligrams of isoflavones per day, simply enjoy 1/2 of a naturally concentrated Revival bar or shake daily (each bar or shake contains 160 milligrams of soy isoflavones). Click here to learn more and try Revival Soy.
What about side effects?
Fortunately, phytoestrogens are well tolerated. Minor stomach cramps and bloating can be associated with intake of soy foods that contain starches. No significant change in vaginal bleeding patterns has been reported with soy supplementation. Excessive soy intake can be associated with thyroid goiter formation. However, this has been linked more to the lack of iodine in the diet and is unlikely to be a problem in individuals who consume an average amount of soy in their diets and who maintain a healthy diet.