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45 CFR 164.502(e), 164.504(e), 164.532(d) and (e) (Download a copy in PDF)


By law, the HIPAA Privacy Rule applies only to covered entities – health plans, health care clearinghouses, and certain health care providers. However, most health care providers and health plans do not carry out all of their health care activities and functions by themselves. Instead, they often use the services of a variety of other persons or businesses. The Privacy Rule allows covered providers and health plans to disclose protected health information to these “business associates” if the providers or plans obtain satisfactory assurances that the business associate will use the information only for the purposes for which it was engaged by the covered entity, will safeguard the information from misuse, and will help the covered entity comply with some of the covered entity’s duties under the Privacy Rule. Covered entities may disclose protected health information to an entity in its role as a business associate only to help the covered entity carry out its health care functions – not for the business associate’s independent use or purposes, except as needed for the proper management and administration of the business associate.

How the Rule Works

General Provision. The Privacy Rule requires that a covered entity obtain satisfactory assurances from its business associate that the business associate will appropriately safeguard the protected health information it receives or creates on behalf of the covered entity. The satisfactory assurances must be in writing, whether in the form of a contract or other agreement between the covered entity and the business associate.

What Is a “Business Associate?” A “business associate” is a person or entity that performs certain functions or activities that involve the use or disclosure of protected health information on behalf of, or provides services to, a covered entity. A member of the covered entity’s workforce is not a business associate. A covered health care provider, health plan, or health care clearinghouse can be a business associate of another covered entity. The Privacy Rule lists some of the functions or activities, as well as the particular services, that make a person or entity a business associate, if the activity or service involves the use or disclosure of protected health information. The types of functions or activities that may make a person or entity a business associate include payment or health care operations activities, as well as other functions or activities regulated by the Administrative Simplification Rules.

Business associate functions and activities include: claims processing or administration; data analysis, processing or administration; utilization review; quality assurance; billing; benefit management; practice management; and repricing. Business associate services are: legal; actuarial; accounting; consulting; data aggregation; management; administrative; accreditation; and financial. See the definition of “business associate” at 45 CFR 160.103.

Examples of Business Associates.

  • A third party administrator that assists a health plan with claims processing.
  • A CPA firm whose accounting services to a health care provider involve access to protected health information.
  • An attorney whose legal services to a health plan involve access to protected health information.
  • A consultant that performs utilization reviews for a hospital.
  • A health care clearinghouse that translates a claim from a non-standard format into a standard transaction on behalf of a health care provider and forwards the processed transaction to a payer.
  • An independent medical transcriptionist that provides transcription services to a physician.
  • A pharmacy benefits manager that manages a health plan’s pharmacist network.

Business Associate Contracts. A covered entity’s contract or other written arrangement with its business associate must contain the elements specified at 45 CFR 164.504(e). For example, the contract must: Describe the permitted and required uses of protected health information by the business associate; Provide that the business associate will not use or further disclose the protected health information other than as permitted or required by the contract or as required by law; and Require the business associate to use appropriate safeguards to prevent a use or disclosure of the protected health information other than as provided for by the contract. Where a covered entity knows of a material breach or violation by the business associate of the contract or agreement, the covered entity is required to take reasonable steps to cure the breach or end the violation, and if such steps are unsuccessful, to terminate the contract or arrangement. If termination of the contract or agreement is not feasible, a covered entity is required to report the problem to the Department of Health and Human Services (HHS) Office for Civil Rights (OCR). Please view our Sample Business Associate Contract.

Transition Provisions for Existing Contracts. Covered entities (other than small health plans) that have an existing contract (or other written agreement) with a business associate prior to October 15, 2002, are permitted to continue to operate under that contract for up to one additional year beyond the April 14, 2003 compliance date, provided that the contract is not renewed or modified prior to April 14, 2003. This transition period applies only to written contracts or other written arrangements. Oral contracts or other arrangements are not eligible for the transition period. Covered entities with contracts that qualify are permitted to continue to operate under those contracts with their business associates until April 14, 2004, or until the contract is renewed or modified, whichever is sooner, regardless of whether the contract meets the Rule’s applicable contract requirements at 45 CFR 164.502(e) and 164.504(e). A covered entity must otherwise comply with the Privacy Rule, such as making only permissible disclosures to the business associate and permitting individuals to exercise their rights under the Rule. See 45 CFR 164.532(d) and (e).

Exceptions to the Business Associate Standard. The Privacy Rule includes the following exceptions to the business associate standard. See 45 CFR 164.502(e). In these situations, a covered entity is not required to have a business associate contract or other written agreement in place before protected health information may be disclosed to the person or entity.

  • Disclosures by a covered entity to a health care provider for treatment of the individual. For example:
    • A hospital is not required to have a business associate contract with the specialist to whom it refers a patient and transmits the patient’s medical chart for treatment purposes.
    • A physician is not required to have a business associate contract with a laboratory as a condition of disclosing protected health information for the treatment of an individual.
    • A hospital laboratory is not required to have a business associate contract to disclose protected health information to a reference laboratory for treatment of the individual.

    Other Situations in Which a Business Associate Contract Is NOT Required.

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    The Best 29 Pain Relief Joint Health Supplements

    After careful deliberation and assessment of hundreds of products, our team of experts came up with the following ranking for the best joint relief supplements available today:

    PureHealth Research Joint Support A natural formula to support the joints and immune system
    PhytAge Labs Joint Relief 911 Supplement based on research on joint health
    BioTRUST Joint 33X: Healthy joints with a three-in-one joint supplement
    ProJoint Plus Composition of herbal extracts to promote healthy bones and joints
    Zenith Labs Joint N-11 Tablets containing the effective compound can promote joint health
    Thrive Health Labs Joint Guard 360 Made from organic ingredients, this solution reduces joint discomfort
    Zenith Labs Longevity Activator This anti-aging blend can address knee and joint issues
    1MD MoveMD A comprehensive solution for reducing joint pain
    Live Conscious Movewell+ It is a comprehensive joint pain remedy with a satisfaction guarantee of 365 days
    Prosper CBD Joint Restore Gummies Dr. Ralph La Guardia has created CBD gummies for arthritis, one of the best options on the market
    UpWellness Golden Revive + This product can reduce knee and joint stiffness within minutes
    CBDPure CBD Infused Cream Joint inflammation and pain are rapidly relieved through its anti-inflammatory properties
    Nuzena Joint Support + The formula was developed by health professionals to ease joint pain and repair cartilage
    Onnit Joint Oil The Onnit philosophy emphasizes quality, efficiency, and effectiveness
    MindBody Matrix Pain Relief Cream The MindBody Matrix can eliminate joint and muscle pain in as little as 30 seconds
    Oweli Move Joint Health Formula Fast joint benefits are provided by the dynamic formula of Oweli Move
    Advanced Bionutritionals Advanced Joint Support Expert-formulated and science-backed supplement for treating joint pain
    Cymbiotika Ultimate Pain Balm Joint pain can be relieved with this topical balm
    3 Naturals Triple Joint Health A scientific study has shown that the Natural Triple formula is effective for reducing pain in the knee joint
    Flexotone Research supports the efficacy of Flexotone as a joint supplement
    Nature Heals Proflexoral Dual-action Japanese formula for improving joint function
    Healthy Back Institute Super Joint Support Compounds of natural ingredients are effective both long- and short-term in relieving pain
    NSP Nutrition Ultra Joint Relief Pro The product is particularly helpful as a joint ache reliever for men
    CellGrail Maximum Flex The ingredients in Maximum Flex are clinically proven to have anti-inflammatory effects
    Nutrition Hacks Joint Pain Hack Using a natural blend of ingredients called ‘Pain Hack’ can reduce joint ache
    Vimerson Health Glucosamine Chondroitin Turmeric & MSM Researchers and nutritionists developed this highly effective and reliable joint formula
    Jocko Joint Warfare Joint Warfare is a formula that provides support and resiliency for your joints
    Move Free Joint Health The benefits of this supplement include treatment for many joint ailments
    Instaflex Instantflex relieves joint stiffness immediately by including eight powerful ingredients

    PureHealth Research Joint Support

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    This joint supplement is among the few supplements developed by a doctor, who also happens to be an expert in natural medicine, Dr. Holly Lucille, ND. It not only relieves pain but also makes your joints more flexible, making even the most painful movements painless.

    PhytAge Labs Joint Relief 911

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    PhytAge Labs, Joint Relief 911, is a healthy joint formula different from many others on this list; Thousands of customers have used it and have been left amazed by how effectively it provided relief. The outcomes of the formula make it worth every single penny of its costs.

    BioTRUST Joint 33X

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    BioTRUST Joint 33X is a unique 3-in-1 formula that helps support joint health. The formula is super-effective in supporting joint function, narrow joint space, and joint flexibility.

    ProJoint Plus

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    ProJoint Plus is a joint supplement made of all-natural ingredients that improve joint function, repair cartilage and bones, and reduce osteoarthritis progression.

    Glucosamine sulfate is one of the best-known and clinically-researched ingredients for relief from pain in joints. The formula relieves pain and repairs damaged joints and bones by providing ample quantities of glucosamine sulfate.

    Zenith Labs Joint N-11

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    Zenith Labs Joint N-11 is a supplement based on extensive research and is one of the rare supplements formulated by doctors. According to the manufacturer, it protects joint cartilage and makes movements painless. The formula helps to improve joint function, including the hands and wrist joints.

    Thrive Health Labs Joint Guard 360

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    Thrive Health Labs Joint Guard 360 is a formula based on the latest research and contains optimum doses of proven ingredients that provide instant relief from pain and prevent it from coming back. It has various health benefits too.

    Zenith Labs Longevity Activator

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    Zenith Labs Longevity Activator is a dietary supplement designed for treating arthritis pain and minimizing the harmful effects of aging on joints and bones. The formula takes a different approach from all other supplements on this list and thus contains a unique blend of ingredients made up of constituents not seen in others.

    1MD MoveMD

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    MoveMD, manufactured by 1MD, is an overall joint health supplement that guarantees reducing pain in the joints within five days. With rich antioxidant properties and anti-inflammatory properties, the MoveMD flushes toxins out of the body and has various other benefits for the body.

    Live Conscious Movewell+

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    Movewell+ is another formula that contains limited ingredients directed explicitly at alleviating joint pain. It relieves all types of joint pains and repairs all the long-term damage done to joints, bones, and cartilages. It works primarily by hydrating joints and contains abundant antioxidants that reduce oxidative stress and end inflammation within the joints.

    Prosper CBD Joint Restore Gummies

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    Joint Restore Gummies, manufactured by Prosper CBD, is a nutritional supplement that takes a different approach to relieve joint pain. The presence of CBD makes it different from most of the formulas available today and unique in its work. It is one of the most effective joint pain relief formulas available today.

    UpWellness Golden Revive+

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    UpWellness Golden Revive+ is another formula developed by doctors and has years of research and experience. Upon daily consumption, the formula guarantees improved mobility and circulation, reduced tissue damage, and an end to inflammation. On top of all these benefits, Golden Revive+ regulates blood cholesterol, improves cardiovascular health, and boosts the body’s immune response.

    CBDPure CBD Infused Cream

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    The CBDPure CBD Infused cream is a topical cream applied directly to the joints and it instantly reduces joint pain. It works by targeting the exact spot and providing comfort. It is different from all other remedies on this list because it is the only topical CBD formula mentioned in this ranking.

    Nuzena Joint Support+

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    Joint Support+ by Nuzena is a joint supplement abundant in glucosamine and chondroitin, two of the best-known and most widely used ingredients to relieve joint pain. It naturally improves the health of joints. Moreover, it is also rich in anti-inflammatory properties and naturally supports bone and cartilage health.

    Onnit Joint Oil

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    Onnit Joint Oil is an omega-3 fatty acid supplement that comes in tangerine flavor and improves joint health and mobility differently than other formulas on this list. The manufacturer ensures the best possible quality coupled with scientific research and third-party lab results, making it one of the most reliable formulas available today.

    MindBody Matrix Pain Relief Cream

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    The MindBody Matrix Pain Relief Cream is one of the top-rated joint supplements. The cream is unlike any other; with over $3 million spent on its development and research, MindBody Matrix cream is supported by various scientific evidence.

    The cream is manufactured inside an LED chamber designed for the sole purpose of putting the formula together. It provides rapid and long-lasting relief from arthritis and reduces joint pain.

    Oweli Move Joint Health Formula

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    Oweli Move Joint Health Formula is a nutritional joint supplement that provides an all-natural solution for pain in joints and fixes all joint-related problems. It works by lubricating joints and improves joint mobility and flexibility.

    The formula is relatively new compared to others on this list. However, due to its scientific backing and the third-party lab results that come with each batch, it has quickly become a trustworthy and well-established remedy for pain in joints.

    Advanced Bionutritionals Advanced Joint Support

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    Advanced Bionutritionals Advanced Joint Support is an efficient, healthy joint supplement that uses a multi-dimensional approach in treating all kinds of pain in joints and providing long-term relief from arthritis.

    Cymbiotika Ultimate Pain Balm

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    The Cymbiotika Ultimate Pain Balm is another topical solution for joint pain; it is among the best joint pain relief ointments and is on track to become number one in its niche. It cures joint and muscle stiffness while significantly improving mobility in joints and flexibility too.

    3 Naturals Triple Joint Health

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    3 Naturals Triple Joint Health is an all-natural supplement among the most famous in the market. It alleviates all joint-related problems; it relieves pain, improves mobility, reduces joint stiffness, reduces swelling, and repairs all damage done to the bones and cartilages.

    Made up of natural extracts from plants and herbs, this pain balm targets the root causes of pain and addresses them appropriately to relieve even the worst cases.


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    Flexotone is a joint supplement that promises relief from chronic arthritis and even the worst pain in joints and degradation. Nevertheless, customer reviews on the website claim that it is one of the most effective formulas. The formula can only be ordered through and is not available on any pharmacy or online store.

    Nature Heals Proflexoral

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    Proflexoral, manufactured by Nature Heals, is labeled as an eight-in-one joint health support formula that helps in treating joint pain and enhances joint health, unlike any other supplement.

    The Proflexoral formula is also one of the few supplements developed by doctors themselves; Dr. Ralph La Guardia based this formula on a groundbreaking discovery he made on a trip to Japan.

    Healthy Back Institute Super Joint Support

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    Super Joint Support is a joint supplement formulated by the Healthy Back Institute; The formula regenerates and repairs cartilages and bone tissues while effectively alleviating all types of pain and discomfort in joints. The product claims to provide rapid relief from even the most severe joint problems and promises to give you your youth back.

    NSP Nutrition Ultra Joint Relief Pro

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    NSP Nutrition Ultra Joint Relief Pro is a chondroitin supplement that reduces joint pain by reducing the effects of aging and minimizing the risk of osteoarthritis.

    Advertised as a supplement for men, the formula promises to boost your workout and help you perform to your fullest in the gym. It uses a blend of all-natural ingredients to provide all the claimed benefits.

    CellGrail Maximum Flex

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    CellGrail Maximum Flex contains a blend of natural ingredients that repair and hydrate joints, relieving joint pain and making them more flexible. It reduces swelling around the joints and bones while relieving all types of joint pain and reducing morning stiffness better than most formulas available today.

    Nutrition Hacks Joint Pain Hack

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    Joint Pain Hack, manufactured by Nutrition Hacks, is a famous nutritional supplement. It uses the mixture of the same ingredients we have seen in most of the formulas; however, the quantities in which it uses those ingredients are a lot higher than other formulas, which is why it guarantees rapid relief and pain alleviation.

    Best Joint Pain Supplements Available On Amazon

    Various supplements can easily be ordered through Amazon; our team of experts analyzed all the formulas available online on Amazon to provide you with the four best-rated aids.

    The following are the best joint health supplements found on Amazon:

    Vimerson Health Glucosamine Chondroitin Turmeric & MSM

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    Vimerson Health Glucosamine Chondroitin Turmeric and MSM are famous turmeric supplements that speak for themselves. It is one of the best-rated on Amazon and has garnered positive reviews, thanks to its positive results.

    It has received more than 22,000 reviews and has an average rating of more than 4.5 stars, which shows why it is one of the best joint pain relief supplements available today.

    Jocko Joint Warfare

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    Jocko Joint Warfare formula uses well-known ingredients and puts them together in a perfect ratio that brings out the best in each constituent. The formula provides long-term relief from joint pain and prevents the effects of aging on joints and bones.

    Move Free Joint Health

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    Move Free Joint Health is among the best and most advanced glucosamine sulfate supplements available today. With more than 12,000 reviews, the formula boasts a near 5-star rating and is considered one of the most affordable and effective solutions for joint health.


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    Instaflex has been rated as a 4.1-star product by nearly 4,000 people, which produces satisfactory results. However, it might not work for everyone; nevertheless, it provides complete relief from even the worst joint pain when it works. The formula is priced at $57 and is one of the most expensive joint health support supplements available today on Amazon.

    How Were The Best Joint Pain Relief Supplements Ranked?

    Our team of experts considered myriad factors to compile the previous ranking. These factors are mentioned below:

    Quality Of The Product:

    The most important category in the ranking was quality; the products that ensured the best quality and were produced in GMP-compliant facilities were ranked higher and given extra points.

    The Ingredients Used:

    The ingredients used to produce the formulas were given special consideration with proven benefits; the products that contained scientifically backed and FDA-approved ingredients (GRAS) were picked over supplements with lesser-known ingredients with no scientific backing.

    Truthful Advertisements:

    Some formulas made inflated claims and promised effects that were not possible in real life. We gave preference to supplements that were honest in their marketing and made realistic claims.

    Best Value For The Money Paid:

    Some supplements cost hundreds of dollars, while others only cost a fraction. The products that justified their price and offered the best value for money were ranked higher than products that did not justify their price.

    Customer Reviews:

    Customer reviews are the best indication of how effective a product is; the products with the best reviews ranked higher than the supplements with no customer reviews backing them.

    Satisfaction Guarantee:

    The manufacturers that backed up their formulas with money-back guarantees preferred our rankings over those with no satisfaction guarantees. No adverse effects have been seen to date.

    The Reputation Of The Manufacturers:

    Some brands have been in the market for years and have established themselves as the epitome of quality, while others are relatively new and lesser-known. The manufacturers with an established reputation of providing the best quality products ranked higher.


    The transparent manufacturers about their sourcing and ingredients scored extra marks in our rankings.

    Expert Input:

    These joint supplements with the involvement of health care experts and doctors in their development were favored over those with no doctors involved in the development process and those products are also favored that are reviewed in academic research institutions.

    Scientific Backing For Joint Supplements

    Various extracts and minerals have been studied for their benefits on the health and mobility of joints. These compounds can provide relief where even the most potent medications do not seem to work.

    If you are experiencing pain in your joints, your doctor may test your vitamin D levels to rule out a deficiency. Several significant studies have linked levels of vitamin D to a lower incidence of arthritis.

    Multiple studies have reported improvements in morning stiffness and joint tenderness with the regular intake of fish oil supplements for up to three months.

    Chondroitin is among the most popular and extensively studied compounds to improve joint health. It is also one of the most commonly found ingredients in the joint supplements mentioned in this ranking. Chondroitin effectively alleviates pain in joints because it is one of the components that form cartilage and plays a vital role in its repair. A study conducted in 2016 concluded that chondroitin improved knee pain by 20%, which shows why it is so copiously found in joint health supplements.

    Glucosamine is another ingredient found in large quantities inside these supplements. It is located in two forms in these supplements: glucosamine hydrochloride and glucosamine sulfate. A study conducted by the NIH found that glucosamine played a vital role in reducing the symptoms of osteoarthritis and provided relief from joint pain while significantly improving joint mobility and flexibility. It also supports cartilages between bones and plays a role in its repair, allowing for better mobility and flexibility and reduced pain during movements.

    Another important constituent of joint health support formulas is turmeric; it is rich in curcumin and is among the most popular extracts for joint pain relief. It works by reducing inflammation within joints and alleviating never-ending pain. A trial undertaken in 2016 found that daily doses of curcumin significantly improved arthritis pain. It is considered one of the most effective remedies for joint pain.

    Boswellia serrata is another extract found abundantly inside the best joint pain relief supplements. It is one of the oldest remedies for pain in joints and has been around in natural medicine for centuries. Boswellia serrata is among the most potent ingredients for joint pain alleviation. The latest research has found that Boswellia serrata is one of the best anti-inflammatory compounds, which is why it is so effective in relieving joint pain.

    Methylsulfonylmethane (MSM) is another compound famous for its effects on joint pain and arthritis. It is present in nearly all of the best joint pain relief supplements. MSM has helped people relieve the pain they thought would stick with them for the rest of their lives; it works when nothing else seems to. Studies have found that it is one of the best remedies for improved joint mobility and joint pain relief.

    Bromelain is an enzyme found abundantly inside pineapples and is well-known for its anti-inflammatory properties. It is a vital constituent of many formulas because of its effects on joint pain and arthritis. Various studies have supported the use of bromelain in relieving joint pain and various other symptoms of arthritis.

    Some joint supplements contain capsaicin, an active ingredient in many topical joint pain relief ointments. Numerous studies support its use that proves its effectiveness against joint pain. Cat’s claw extract is another ingredient with anti-inflammatory and immunity-boosting properties, making it an essential constituent of various well-known formulas. Stinging nettle extract is another popular extract similar to a cat’s claw; it has well-documented anti-inflammatory and immunity-enhancing properties, making it a vital component of joint pain relief supplements.

    All the supplements mentioned in our rankings contain science-backed ingredients and are natural alternatives to traditional joint supplements. This is why they are so effective in providing relief from even the worst cases of knee osteoarthritis and arthritis.

    Frequently Asked Questions

    Our team of experts gets myriad questions regarding these joint supplements daily; the most important of those questions are answered below.

    Q: What is the cause of pain in the joints?

    A: The most basic cause of this pain is damaged cartilages in between bones, which can result from aging, injury, and diseases like arthritis. Nevertheless, there are some other reasons for pain and inflammation, including swelling within joints, muscle spasms and soreness, immunity disorder, and deficiency of essential nutrients, among other things.

    Q: What are the best topical remedies to reduce pain in joints?

    A: The creams and ointments containing methyl salicylate, CBD, and capsaicin are among the best topical remedies for reducing pain in the joints. All of the topical creams on our list are among the best in the market and work as best to ease the pain.

    Q: How can I sleep with joint pain?

    A: This pain can cause problems with sleep; it is advised to take painkillers, joint supplements, and sleeping aids to help with better sleep.

    Q: Which types of food make joint pain worse?

    A: Foods that contain high amounts of sugar, saturated fat, trans fat, refined carbohydrates, and omega-6 fatty acids can make the pain in joints much worse. Excessive alcohol consumption is also detrimental to the joints.

    Q: Can cold weather make joint pain worse?

    A: Yes, cold weather increases the risk of pain in joints and makes existing pain worse.

    Best Joint Health Supplements-Final Verdict

    The joint supplements available in the market promise to relieve pain from joints; however, only a few live up to their claims. After careful deliberation, our team of experts has compiled the list of the best joint supplements on the market today.

    Each of the formulas featured here has been tested and guarantees relief from severe pain in joints and arthritis. These joint supplements are available online and can be ordered with a single click.

    Affiliate Disclosure:

    The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.


    Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

    The news and editorial staff of Sound Publishing, Inc. had no role in the preparation of this post. The views and opinions expressed in this sponsored post are those of the advertiser and do not reflect those of Sound Publishing, Inc.

    Sound Publishing, Inc. does not accept liability for any loss or damages caused by the use of any products, nor do we endorse any products posted in our Marketplace.