Bronson Reactiv-8 Reviews

At the time of this writing, you could only get the product on the official Bronson website.

Bronson Reactiv-8 Reviews – Does This Product Really Work?

We, Health Web Magazine, the owner of this e-commerce website, fully intends to comply with the rules of the Federal Trade Commission (FTC) regarding the use of endorsements, testimonials, and general advertising and marketing content. As a visitor to Health Web Magazine you should be aware that we may receive a fee for any products or services sold through this site.

Content

This content may contain all or some of the following – product information, overviews, product specifications, and buying guides. All content is presented as a nominative product overview and registered trademarks, trademarks, and service-marks that appear on Health Web Magazine belong solely to their respective owners. If you see any content that you deem to be factually inaccurate, we ask that you contact us so we can remedy the situation. By doing so, we can continue to provide information that our readers can rely on for truth and accuracy.

Our Top Selections Box – Promotional Sales

Products shown in the section titled ‘Our Top Products’ are those that we promote as the owner and/ or reseller and does not represent all products currently on the market or companies manufacturing such products. In order to comply fully with FTC guidelines, we would like to make it clear that any and all links featured in this section are sales links; whenever a purchase is made via one of these links we will receive compensation. Health Web Magazine is an independently owned website and all opinions expressed on the site are our own or those of our contributors. Regardless of product sponsor relations, all editorial content found on our site is written and presented without bias or prejudice.

Something we believe is that every page on the website should be created for a purpose. Our Quality Page Score is therefore a measurement of how well a page achieves that purpose. A page’s quality score is not an absolute score however, but rather a score relative to other pages on the website that have a similar purpose. It has nothing to do with any product ratings or rankings. It’s our internal auditing tool to measure the quality of the on the page content. There are a number of factors that determine the Page Score of a given page. Landing page quality is a factor in determining Page Score. Landing page quality generally refers to whether or not the overall page contains relevant and original content to the web page visitor. The content quality value of a web page is determined by comparing a page to known quality patterns and each pattern carries a different weighting in how it affects the overall content quality value of a page. We also factor in user generated feedback on this form plus a page quality algorithm. Since web pages content can change, the content quality value of a web page is updated periodically.

Please declare your traffic by updating your user agent to include company specific information.

More Information

Internet Security Policy

By using this site, you are agreeing to security monitoring and auditing. For security purposes, and to ensure that the public service remains available to users, this government computer system employs programs to monitor network traffic to identify unauthorized attempts to upload or change information or to otherwise cause damage, including attempts to deny service to users.

Unauthorized attempts to upload information and/or change information on any portion of this site are strictly prohibited and are subject to prosecution under the Computer Fraud and Abuse Act of 1986 and the National Information Infrastructure Protection Act of 1996 (see Title 18 U.S.C. §§ 1001 and 1030).

To ensure our website performs well for all users, the SEC monitors the frequency of requests for SEC.gov content to ensure automated searches do not impact the ability of others to access SEC.gov content. We reserve the right to block IP addresses that submit excessive requests. Current guidelines limit users to a total of no more than 10 requests per second, regardless of the number of machines used to submit requests.

If a user or application submits more than 10 requests per second, further requests from the IP address(es) may be limited for a brief period. Once the rate of requests has dropped below the threshold for 10 minutes, the user may resume accessing content on SEC.gov. This SEC practice is designed to limit excessive automated searches on SEC.gov and is not intended or expected to impact individuals browsing the SEC.gov website.

Note that this policy may change as the SEC manages SEC.gov to ensure that the website performs efficiently and remains available to all users.

Note: We do not offer technical support for developing or debugging scripted downloading processes.

Immune checkpoint inhibitors (ICI) such as cytotoxic T-cell lymphocyte associated antigen-4 (CTLA-4) and programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) blocking agents are indicated as a standard of care in several cancers [1,2,3]. Their use is expected to expand, including in the adjuvant setting, leading to an increase in the population of cancer patients exposed to these therapies [4,5,6,7,8]. However, the clinical benefit of ICIs can be limited by toxicities caused by off-target inflammatory and autoimmune responses, which can be life-threatening, and may require treatment discontinuation and initiation of immunosuppressants. A challenging population is patients who have a dual diagnosis of autoimmune diseases and cancer, requiring the use of ICIs [9,10,11]. A recent systematic review of the literature summarized the evidence on adverse events associated with ICI use in patients with preexisting autoimmune diseases and found that most of these patients (75%) are susceptible to develop flare of the underlying autoimmunity (50%), and/or new onset immune-related adverse events (irAEs) (34%) [9]. Although adverse events improved in most patients (90%), some (17%) required permanent ICI discontinuation or remained at risk of serious complications including fatality (4%).

Methods

Patients

Following institutional review board approval, we searched the institutional databases of the MD Anderson Cancer Center to identify cancer patients who received at least one dose of an FDA-approved ICI (ipilimumab, nivolumab, pembrolizumab, atezolizumab, durvalumab, or avelumab) between January 2011 and December 2018. Patients who had a diagnosis of MG preceding or following the initiation of ICI in the cohort were identified.

We also searched Medline, Web of Science, PubMed ePubs, EMBASE and the Cochrane library through August 2018, with no language or study design restrictions, for case reports, series and observational studies that described patients with cancer and MG receiving ICI. Search strategy and terms are provided in Additional file 1. Titles and abstracts were screened by three independent investigators (in pairs) to identify potentially relevant articles. Then, full text of selected articles was retrieved and reviewed. References of the included articles were hand-searched. A detailed clinical description of each patient was generated. Disagreements were resolved by consensus.

For both MD Anderson and literature identified cases, definite diagnosis of MG was considered on the basis of having ocular and/or systemic muscle weakness, and at least one of the following criteria: (1) elevated titers of anti-acetylcholine receptor (AChR) antibodies, (2) findings suggestive of MG on electrodiagnostic studies, (3) positive edrophonium test, or (4) positive ice pack test. Probable diagnosis of MG was also considered based on the neurologist’s report confirming the diagnosis of MG on the basis of high clinical suspicion alone.

Methods

For both the MD Anderson and literature identified patients, we extracted data on patient demographics and baseline characteristics (age, gender, type of ICI, type of cancer, and history of comorbidities). We assessed the clinical severity of ICI-related MG using the Myasthenia Gravis Foundation of America (MGFA) classification. Briefly, MGFA class I is defined as weakness isolated to ocular muscles, and MGFA classes II as mild weakness involving any other muscles. MGFA class III and IV are defined by moderate and severe muscle weakness, respectively. MGFA class V is defined as myasthenic crisis involving respiratory failure requiring endotracheal intubation or non-invasive positive pressure mechanical ventilation. Adverse events outcomes were defined as completely resolved, improved, or deteriorated according to the available last follow-up. Tumor response to ICI for MD Anderson patients was categorized using the Response Evaluation Criteria in Solid Tumors 1.1. For patients identified from the literature, response was characterized based on the authors’ report, while remaining cognizant of this limitation. We assessed the quality of the cases identified from the literature using the recommended guidelines for publishing adverse event reports [20]. Data were extracted and quality was assessed by one reviewer and crosschecked by another. Disagreements were resolved by consensus.

Outcomes analysis

We used descriptive statistics to summarize the data, with median and range for continuous variables and frequencies and percentages for categorical variables. The chi-squared and Fisher’s exact tests were used to compare categorical variables, and the Wilcoxon test or Kruskal-Wallis test was used to compare continuous variables between groups. Timing to respiratory failure after ICI initiation was estimated using the Kaplan-Meier method, and times were right-censored at the last available follow-up.

Wiley is a global provider of content and content-enabled workflow solutions in areas of scientific, technical, medical, and scholarly research; professional development; and education. Our core businesses produce scientific, technical, medical, and scholarly journals, reference works, books, database services, and advertising; professional books, subscription products, certification and training services and online applications; and education content and services including integrated online teaching and learning resources for undergraduate and graduate students and lifelong learners. Founded in 1807, John Wiley & Sons, Inc. has been a valued source of information and understanding for more than 200 years, helping people around the world meet their needs and fulfill their aspirations. Wiley has published the works of more than 450 Nobel laureates in all categories: Literature, Economics, Physiology or Medicine, Physics, Chemistry, and Peace. Wiley has partnerships with many of the world’s leading societies and publishes over 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols in STMS subjects. With a growing open access offering, Wiley is committed to the widest possible dissemination of and access to the content we publish and supports all sustainable models of access. Our online platform, Wiley Online Library (wileyonlinelibrary.com) is one of the world’s most extensive multidisciplinary collections of online resources, covering life, health, social and physical sciences, and humanities.

  • Access supplemental materials and multimedia.
  • Unlimited access to purchased articles.
  • Ability to save and export citations.
  • Custom alerts when new content is added.

A reanalysis of first-year longitudinal data on infants’ reactions to a stranger suggests that 2 distinct mechanisms may be promoting aversive “stranger reactions.” Up through the middle of the first year occasional signs of uneasiness are attributed to a wariness of the unfamiliar; such reactions are more likely to occur in highly “reactive” infants. By around age 9 months, however, learned aversions which have their roots in prior disturbing experiences may become an important additional determinant that can supplement or override a baby’s earlier proclivities.

As the flagship journal of the Society for Research in Child Development, Child Development has published articles, essays, reviews, and tutorials on various topics in the field of child development since 1930. Spanning many disciplines, the journal provides the latest research, not only for researchers and theoreticians, but also for child psychiatrists, clinical psychologists, psychiatric social workers, specialists in early childhood education, educational psychologists, special education teachers, and other researchers.

Wiley is a global provider of content and content-enabled workflow solutions in areas of scientific, technical, medical, and scholarly research; professional development; and education. Our core businesses produce scientific, technical, medical, and scholarly journals, reference works, books, database services, and advertising; professional books, subscription products, certification and training services and online applications; and education content and services including integrated online teaching and learning resources for undergraduate and graduate students and lifelong learners. Founded in 1807, John Wiley & Sons, Inc. has been a valued source of information and understanding for more than 200 years, helping people around the world meet their needs and fulfill their aspirations. Wiley has published the works of more than 450 Nobel laureates in all categories: Literature, Economics, Physiology or Medicine, Physics, Chemistry, and Peace. Wiley has partnerships with many of the world’s leading societies and publishes over 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols in STMS subjects. With a growing open access offering, Wiley is committed to the widest possible dissemination of and access to the content we publish and supports all sustainable models of access. Our online platform, Wiley Online Library (wileyonlinelibrary.com) is one of the world’s most extensive multidisciplinary collections of online resources, covering life, health, social and physical sciences, and humanities.

This item is part of a JSTOR Collection.
For terms and use, please refer to our Terms and Conditions
Child Development © 1978 Society for Research in Child Development
Request Permissions