That all sounds great, but what are adaptogens, exactly, and do they really do all these things? Adaptogens are natural substances, typically derived from plants, that supposedly help the body counteract and adapt to stress. Sounds like a win-win, but when I dug into the research, I uncovered some problems: The science on adaptogens is still heavy on hope and light on evidence. And there are reasons to question whether chemicals that combat biological stress would be universally beneficial.

Read This Before Spending Money on Adaptogens for Stress Relief (or Anything Else)

Are you feeling vaguely tired, anxious, maybe stressed? Don’t blame current events or the looming holiday season—your body’s stress response system is probably out of whack. At least, that’s what integrative medicine doctors across the country will tell you, and they’ll be happy to sell you some trendy cures, too—herbs they might refer to as “adaptogens.” Over at MindBodyGreen, functional medicine practitioner William Cole touts that adaptogens strengthen your nails, improve your complexion, balance your hormones, give you more energy, boost your sex drive, fight infections, sharpen your memory, ease depression, improve your blood sugar, reduce bloating and gas, and even fight cancer.

That all sounds great, but what are adaptogens, exactly, and do they really do all these things? Adaptogens are natural substances, typically derived from plants, that supposedly help the body counteract and adapt to stress. Sounds like a win-win, but when I dug into the research, I uncovered some problems: The science on adaptogens is still heavy on hope and light on evidence. And there are reasons to question whether chemicals that combat biological stress would be universally beneficial.

As I’ve written before, it’s really, really crucial that potential new remedies be carefully studied in people before being touted and sold as medical treatments—that’s true of so-called “natural” remedies as well as synthetic drugs. Yet while dozens of adaptogens are being recommended by alternative doctors as safe and effective cures for common ailments—Cole mentions more than 20 in his MindBodyGreen article—very, very few studies on adaptogens have been published. Take the chaga mushroom, an adaptogen Cole says will “keep skin youthful.” I searched through the U.S. National Library of Medicine’s database of more than 27 million published study abstracts and couldn’t find a single study in which researchers gave chaga to human beings for any reason, let alone to determine if the fungus slows down aging in the skin.

Other recommended adaptogens have been studied in people but haven’t proven particularly effective. Take Panax (Asian) ginseng, which, according to functional medicine doctor Josh Axe, is “the most well-known adaptogen” and also “considered the most potent” for boosting mental performance and reducing stress. A recent systematic review published by the Cochrane Collaboration, a highly respected independent organization that gathers and summarizes healthcare-related research, concluded that “there is a lack of convincing evidence to show a cognitive enhancing effect of Panax ginseng in healthy participants.” Another recent paper reported that while more research should certainly be done on Panax ginseng, “there is no conclusive evidence supporting its use in the treatment of any particular disease.” For the adaptogen considered the most potent and famous, Dr. Axe, this is pretty disappointing.

Anyone who is suffering from high stress can take Primal Calm. It may also help the user find relief for mild depression. However, it may not be effective for serious cases of depression. It would be best to consult your doctor if you’re interested in taking this or other stress and depression relief supplements.

What Is Primal Calm?

Primal Calm is a stress management supplement that is popularly used for treating high stress levels or mild depression. It provides nutritional support for the body’s natural stress management systems. It contains all-natural, researched and proven anti-stress nutrients to help control stress and other problems related to it.

The supplement comes in easy to swallow capsules for convenience. It claims to have noticeable effects in as little as 30 minutes of intake. However, it also provides long-term anti-stress effects with usage over a longer time period. It is non-drowsy, non-stimulant and doesn’t have any known side effect.

No, Adaptogenic Calm is a dietary supplement that works with your body’s natural chemistry, providing raw materials and co-factors to support the structure and function of specific anti-stress systems so that your body can better achieve a more normal and healthy state.

Anyone who feels that stress is interfering with his or her productiveness, effectiveness or enjoyment of life. We always recommend checking with one’s Primary Care Provider before adding any dietary supplement into their regime to cater to each individual’s needs.

Adaptogenic Calm is the ultimate natural stress-fighting formula. The formula contains more of the top anti-stress nutrients than any other stress-fighting supplement. It was designed to be a convenient alternative to traditional stress-fighting supplements, using the purest and most up-to-date, well-researched and patented ingredients.

Adaptogenic Calm was designed for use by virtually everyone. The ingredients in Adaptogenic Calm are all regarded as safe by the U.S. Food and Drug Administration. If you are under a physician’s care, pregnant, lactating or taking prescription medications, we always suggest that you consult with your physician before starting any new supplement program.

None of the ingredients in Adaptogenic Calm have been shown to produce side effects when taken as directed.

Other stress formulas might contain stress-specific nutrients, but are often present in very low doses and almost never all together in the same all-in-one formula. Consequently, other stress formulas don’t provide the true broad support your anti-stress systems require to deal most effectively with stress.

No, Adaptogenic Calm is a dietary supplement that works with your body’s natural chemistry, providing raw materials and co-factors to support the structure and function of specific anti-stress systems so that your body can better achieve a more normal and healthy state.

There is no “right time” to take Adaptogenic Calm. It can be taken morning, noon or night, depending on when it’s most convenient (with a little food is best). If you have a stressful day coming up, it may help to take some with breakfast.

It will vary between individuals.

Cortisol is one of the “fight-or-flight” hormones secreted by the adrenals in response to stress. Some cortisol is necessary for good health, but at high levels, it is associated with loss of muscle tone, increased fat deposition, immune suppression, depression, fatigue and reduced calcium uptake by bones.

If for any reason you are not completely satisfied with any of our products or have a less than satisfactory experience, please contact our customer service specialists within 30 days of the receipt of your order.

Information is subject to change and packaging may not be an exact match to labels and packaging in the marketplace.

The product is reasonably priced on the market.

Who Is The Manufacturer Of Adaptogenic Calm?

Primal Nutrition, LLC manufactures Adaptogenic Calm. The company is the brainchild of Mark Sisson. Primal Blueprint helps the consumers with a wide range of health supplements, online courses to stay fit and lose weight, diet plans, and recipes to increase longevity and wellness.

However, the official website does not disclose how the company sources the ingredients, what tests are conducted to ensure their purity, safety, and efficacy. There’s no information on where the product is manufactured. As the FDA does not evaluate dietary supplements, such information helps the buyer make an informed decision.

Adaptogenic Calm Review – Health Web Magazine Images

Parisi A, Tranchita E, Duranti G, et al. Effects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary results. J Sports Med Phys Fitness 2010;50:57-63. View abstract.

Moderate Interaction

Be cautious with this combination

Medications for diabetes (Antidiabetes drugs) interacts with RHODIOLA

Rhodiola might lower blood sugar levels. Taking rhodiola along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.

Medications for high blood pressure (Antihypertensive drugs) interacts with RHODIOLA

Rhodiola might lower blood pressure. Taking rhodiola along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.

Medications that decrease the immune system (Immunosuppressants) interacts with RHODIOLA

Rhodiola can increase the activity of the immune system. Some medications, such as those used after a transplant, decrease the activity of the immune system. Taking rhodiola along with these medications might decrease the effects of these medications.

Medications moved by pumps in cells (P-Glycoprotein Substrates) interacts with RHODIOLA

Some medications are moved in and out of cells by pumps. Rhodiola might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.

Losartan (Cozaar) interacts with RHODIOLA

Rhodiola might change how the body breaks down losartan. Taking rhodiola along with losartan might increase the effects and side effects of losartan.

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with RHODIOLA

Some medications are changed and broken down by the liver. Rhodiola might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Minor Interaction

Be watchful with this combination

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with RHODIOLA

Some medications are changed and broken down by the liver. Rhodiola might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with RHODIOLA

Some medications are changed and broken down by the liver. Rhodiola might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Begum, V. H. and Sadique, J. Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats. Indian J Exp Biol. 1988;26(11):877-882. View abstract.

Dosing

Ahumada F, Aspee F, Wikman G, and et al. Withania somnifera extract. Its effect on arterial blood pressure in anaesthetized dogs. Phytotherapy Research 1991;5:111-114.

Anbalagan K and Sadique J. Withania somnifera (ashwagandha), a rejuvenating herbal drug which controls alpha-2 macroglobulin synthesis during inflammation. Int.J.Crude Drug Res. 1985;23(4):177-183.

Anbalagan, K. and Sadique, J. Influence of an Indian medicine (Ashwagandha) on acute-phase reactants in inflammation. Indian J Exp Biol. 1981;19(3):245-249. View abstract.

Begum, V. H. and Sadique, J. Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats. Indian J Exp Biol. 1988;26(11):877-882. View abstract.

Bhat, J., Damle, A., Vaishnav, P. P., Albers, R., Joshi, M., and Banerjee, G. In vivo enhancement of natural killer cell activity through tea fortified with Ayurvedic herbs. Phytother.Res 2010;24(1):129-135. View abstract.

Bhattacharya, S. K. and Muruganandam, A. V. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol Biochem.Behav 2003;75(3):547-555. View abstract.

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Choudhary, M. I., Nawaz, S. A., ul-Haq, Z., Lodhi, M. A., Ghayur, M. N., Jalil, S., Riaz, N., Yousuf, S., Malik, A., Gilani, A. H., and ur-Rahman, A. Withanolides, a new class of natural cholinesterase inhibitors with calcium antagonistic properties. Biochem.Biophys.Res Commun. 8-19-2005;334(1):276-287. View abstract.

Davis, L. and Kuttan, G. Effect of Withania somnifera on DMBA induced carcinogenesis. J Ethnopharmacol. 2001;75(2-3):165-168. View abstract.

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Devi, P. U., Sharada, A. C., and Solomon, F. E. Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma-180. Indian J Exp Biol. 1993;31(7):607-611. View abstract.

Devi, P. U., Sharada, A. C., and Solomon, F. E. In vivo growth inhibitory and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma. Cancer Lett. 8-16-1995;95(1-2):189-193. View abstract.

Devi, P. U., Sharada, A. C., Solomon, F. E., and Kamath, M. S. In vivo growth inhibitory effect of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma 180. Indian J Exp Biol. 1992;30(3):169-172. View abstract.

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Gupta, S. K., Dua, A., and Vohra, B. P. Withania somnifera (Ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidative modifications. Drug Metabol.Drug Interact. 2003;19(3):211-222. View abstract.

Kaur, K., Rani, G., Widodo, N., Nagpal, A., Taira, K., Kaul, S. C., and Wadhwa, R. Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha. Food Chem.Toxicol. 2004;42(12):2015-2020. View abstract.

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Lu, L., Liu, Y., Zhu, W., Shi, J., Liu, Y., Ling, W., and Kosten, T. R. Traditional medicine in the treatment of drug addiction. Am J Drug Alcohol Abuse 2009;35(1):1-11. View abstract.

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Malhotra, C. L., Mehta, V. L., Prasad, K., and Das, P. K. Studies on Withania ashwagandha, Kaul. IV. The effect of total alkaloids on the smooth muscles. Indian J Physiol Pharmacol. 1965;9(1):9-15. View abstract.

Malviya, N., Jain, S., Gupta, V. B., and Vyas, S. Recent studies on aphrodisiac herbs for the management of male sexual dysfunction–a review. Acta Pol.Pharm. 2011;68(1):3-8. View abstract.

Mikolai, J., Erlandsen, A., Murison, A., Brown, K. A., Gregory, W. L., Raman-Caplan, P., and Zwickey, H. L. In vivo effects of Ashwagandha (Withania somnifera) extract on the activation of lymphocytes. J.Altern.Complement Med. 2009;15(4):423-430. View abstract.

Praveenkumar, V., Kuttan, R., and Kuttan, G. Chemoprotective action of Rasayanas against cyclosphamide toxicity. Tumori 8-31-1994;80(4):306-308. View abstract.

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Sharada, A. C., Solomon, F. E., Devi, P. U., Udupa, N., and Srinivasan, K. K. Antitumor and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma in vivo. Acta Oncol. 1996;35(1):95-100. View abstract.

Singh, R. H., Narsimhamurthy, K., and Singh, G. Neuronutrient impact of Ayurvedic Rasayana therapy in brain aging. Biogerontology. 2008;9(6):369-374. View abstract.

Tohda, C. [Overcoming several neurodegenerative diseases by traditional medicines: the development of therapeutic medicines and unraveling pathophysiological mechanisms]. Yakugaku Zasshi 2008;128(8):1159-1167. View abstract.

Upadhaya L and et al. Role of an indigenous drug Geriforte on blood levels of biogenic amines and its significance in the treatment of anxiety neurosis. Acta Nerv Super 1990;32(1):1-5.

Vaishnavi, K., Saxena, N., Shah, N., Singh, R., Manjunath, K., Uthayakumar, M., Kanaujia, S. P., Kaul, S. C., Sekar, K., and Wadhwa, R. Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences. PLoS.One. 2012;7(9):e44419. View abstract.

Ven Murthy, M. R., Ranjekar, P. K., Ramassamy, C., and Deshpande, M. Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha. Cent.Nerv.Syst.Agents Med.Chem. 9-1-2010;10(3):238-246. View abstract.

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Agarwal R, Diwanay S, Patki P, Patwardhan B. Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. J Ethnopharmacol 1999;67:27-35. View abstract.

Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Indian J Pharmacol. 2013;45(4):417-8. View abstract.

Ahmad MK, Mahdi AA, Shukla KK, et al. Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males. Fertil Steril 2010;94:989-96. View abstract.

Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Its effects on arterial blood pressure in anaesthetized dogs. Phytother Res 1991;5:111-14.

Ambiye VR, Langade D, Dongre S, Aptikar P, Kulkarni M, Dongre A. Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. Evid Based Complement Alternat Med. 2013;2013:571420. View abstract.

Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000;38:607-9. View abstract.

Archana R, Namasivayam A. Antistressor effect of Withania somnifera. J Ethnopharmacol 1999;64:91-3. View abstract.

Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. Indian J Exp Biol 1997;35:236-9. View abstract.

Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integr Cancer Ther. 2013;12(4):312-22. View abstract.

Björnsson HK, Björnsson ES, Avula B, et al. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Liver Int. 2020;40(4):825-829. View abstract.

Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozola-Martínez A, Kreider RB. Effects of ashwagandha (Withania somnifera) on physical performance: systematic review and Bayesian meta-analysis. J Funct Morphol Kinesiol. 2021 Feb 11;6(1):20. doi: 10.3390/jfmk6010020. View abstract.

Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-62. View abstract.

Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. PLoS One 2021;16(9):e0257843. View abstract.

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Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. View abstract.

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Durg S, Bavage S, Shivaram SB. Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Phytother Res. 2020;34(5):1041-1059. View abstract.

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Gopal S, Ajgaonkar A, Kanchi P, et al. Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. J Obstet Gynaecol Res 2021. View abstract.

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Kumar G, Srivastava A, Sharma SK, Rao TD, Gupta YK. Efficacy and safety evaluation of ayurvedic treatment (ashwagandha powder and sidh makardhwaj) in rheumatoid arthritis patients: a pilot perspective study. Indian J Med Res 2015 Jan;141(1):100-6. View abstract.

Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019;98(37):e17186. View abstract.

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Nagashayana N, Sankarankutty P, Nampoothiri MRV, et al. Association of l-DOPA with recovery following Ayurveda medication in Parkinson’s Disease. J Neurol Sci 2000;176:124-7. View abstract.

Panda S, Kar A. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol 1998;50:1065-68. View abstract.

Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67:233-39. View abstract.

Pérez-Gómez J, Villafaina S, Adsuar JC, Merellano-Navarro E, Collado-Mateo D. Effects of ashwagandha (Withania somnifera) on VO2max: A systematic review and meta-analysis. Nutrients. 2020;12(4):1119. View abstract.

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Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. J Clin Med 2021;10(16):3644. View abstract.

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