Memorall reviews

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Memorall Reviews

If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.

Overview

Name: Huperzine A
Synonyms: ZT-1, DEBIO 9902 , Qian ceng ta, Cerebra capsule, Pharmassure Memorall capsule
Therapy Type: Small Molecule (timeline), Supplement, Dietary (timeline)
Target Type: Cholinergic System (timeline)
Condition(s): Alzheimer’s Disease
U.S. FDA Status: Alzheimer’s Disease (Inactive)
Company: Debiopharm Group™, Neuro-Hitech, Inc.
Approved for: None

Background

Huperzine A is an alkaloid extract derived from the Chinese club moss Huperzia serrata. Huperzine A for many years has been widely used in traditional Chinese medicine to enhance memory and to treat fever and inflammation. In the United States it is commercially available as a food supplement, but has not been approved by the FDA as a treatment for AD or other cognition disorders.

Multiple proposed mechanisms of action for huperzine A can be found in the literature. It is a selective AChE inhibitor. It also been shown to have antioxidant and neuroprotective properties counteracting glutamate-induced toxicity, possibly by interacting with NMDA receptors (Ashani et al., 1994; Ved et al., 1997; Zhang et al., 2001; Gordon et al., 2001; Bai et al., 2000).

Research on huperzine A originated with the Chinese Academy of Sciences. The Mayo Clinic, Jacksonville, Florida, generated a version of huperzine A that was tested at Georgetown University, Washington, D.C., and licensed to the biotechnology company Neuro-Hitech to develop an oral formulation for clinical development. Preclinical studies of this compound suggested blood-brain barrier penetration and good tolerability and the same mechanism of action as the original Chinese extract (Neuro Hi-Tech media release). Additional formulations of huperzine A exist, as well.

Findings

Between 2004 and 2007, Neuro-Hitech’s oral formulation of huperzine A completed a Phase 2 clinical trial in the United States for the treatment of Alzheimer’s disease. Conducted by the Alzheimer Disease Cooperative Study, this multicenter, four-month trial compared two doses of huperzine to placebo in 210 people with mild to moderate AD. This trial was negative on its primary endpoint, but secondary analyses indicated a trend toward cognitive improvement on the higher dose (Rafii et al., 2011). Side effects, mostly nausea and vomiting, were mild to moderate. Development of this formulation has been discontinued.

A second trial, of a sustained-release formulation developed by Shandong Luye Pharmaceutical Co., Ltd., began in 2010 and was estimated to run for two years. According to clinicaltrials.gov, this Phase 2/3 study was conducted at the Shanghai Mental Health Center, to compare a six-month course of two doses to placebo in 390 people with mild to moderate Alzheimer’s disease. The status of this trial is unknown and data are unavailable.

The Swiss company Debiopharm tested a synthetic huperzine derivative and prodrug, ZT-1, aka DEBIO 9902. It was reported to be well-tolerated, rapidly absorbed, and converted into huperzine A, in a small Phase 1 trial in healthy Chinese volunteers ( Jia et al., 2013). However, clinical development of DEBIO 9902 has been discontinued.

Previously, clinical trials conducted in China had reported beneficial effects on cognition. These were two-week to two-month trials in 60, 103, and 160 patients with dementia, respectively (see Xu et al., 1999; Xu et al., 1995).

A published meta-analysis of 20 huperzine clinical trials conducted in China, Europe, and the United States leaves open the question of whether huperzine could be therapeutically useful. Trials reporting beneficial effects have tended to be small and of short duration (Yang et al., 2013). A separate attempt to evaluate clinical trials of huperzine A for mild cognitive impairment found no studies that met inclusion criteria for meta-analysis, that is, randomised, parallel-group, placebo-controlled trials (Yue et al., 2012). Research on huperzine A continues.

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References

Paper Citations

  1. Rafii MS, Walsh S, Little JT, Behan K, Reynolds B, Ward C, Jin S, Thomas R, Aisen PS, . A phase II trial of huperzine A in mild to moderate Alzheimer disease. Neurology . 2011 Apr 19;76(16):1389-94. PubMed.
  2. Jia JY, Zhao QH, Liu Y, Gui YZ, Liu GY, Zhu DY, Yu C, Hong Z. Phase I study on the pharmacokinetics and tolerance of ZT-1, a prodrug of huperzine A, for the treatment of Alzheimer’s disease. Acta Pharmacol Sin . 2013 Jul 5;34(7):976-82. PubMed.
  3. Xu SS, Cai ZY, Qu ZW, Yang RM, Cai YL, Wang GQ, Su XQ, Zhong XS, Cheng RY, Xu WA, Li JX, Feng B. Huperzine-A in capsules and tablets for treating patients with Alzheimer disease. Zhongguo Yao Li Xue Bao . 1999 Jun;20(6):486-90. PubMed.
  4. Xu SS, Gao ZX, Weng Z, Du ZM, Xu WA, Yang JS, Zhang ML, Tong ZH, Fang YS, Chai XS. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer’s disease. Zhongguo Yao Li Xue Bao . 1995 Sep;16(5):391-5. PubMed.
  5. Yang G, Wang Y, Tian J, Liu JP. Huperzine a for Alzheimer’s disease: a systematic review and meta-analysis of randomized clinical trials. PLoS One . 2013;8(9):e74916. Epub 2013 Sep 23 PubMed.
  6. Yue J, Dong BR, Lin X, Yang M, Wu HM, Wu T. Huperzine A for mild cognitive impairment. Cochrane Database Syst Rev . 2012;12:CD008827. PubMed.
  7. Ashani Y, Grunwald J, Kronman C, Velan B, Shafferman A. Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase. Mol Pharmacol . 1994 Mar;45(3):555-60. PubMed.
  8. Ved HS, Koenig ML, Dave JR, Doctor BP. Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate. Neuroreport . 1997 Mar 3;8(4):963-8. PubMed.
  9. Zhang JM, Hu GY. Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons. Neuroscience . 2001;105(3):663-9. PubMed.
  10. Gordon RK, Nigam SV, Weitz JA, Dave JR, Doctor BP, Ved HS. The NMDA receptor ion channel: a site for binding of Huperzine A. J Appl Toxicol . 2001 Dec;21 Suppl 1:S47-51. PubMed.
  11. Bai DL, Tang XC, He XC. Huperzine A, a potential therapeutic agent for treatment of Alzheimer’s disease. Curr Med Chem . 2000 Mar;7(3):355-74. PubMed.

External Citations

Further Reading

Papers

  1. Nie H, Wang Z, Zhao W, Lu J, Zhang C, Lok K, Wang Y, Shen H, Xu Z, Yin M. New nicotinic analogue ZY-1 enhances cognitive functions in a transgenic mice model of Alzheimer’s disease. Neurosci Lett . 2013 Mar 14;537:29-34. PubMed.
  2. Rispoli V, Ragusa S, Nisticò R, Marra R, Russo E, Leo A, Felicitá V, Rotiroti D. Huperzine a restores cortico-hippocampal functional connectivity after bilateral AMPA lesion of the nucleus basalis of meynert. J Alzheimers Dis . 2013 Jan 1;35(4):833-46. PubMed.
  3. Zhang L, Song Y, Lu C, Zhang J, Yuan J, Wang T, Fu F. The effects of huperzine A on gastrointestinal acetylcholinesterase activity and motility after single and multiple dosing in mice. Exp Ther Med . 2013 Mar;5(3):793-796. PubMed.
  4. Wei G, Xiao S, Lu R, Liu C. Simultaneous determination of ZT-1 and its metabolite Huperzine A in plasma by high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Analyt Technol Biomed Life Sci . 2006 Jan 2;830(1):120-5. Epub 2005 Nov 8 PubMed.

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Memorall Reviews

Memorall is a brain supplement which is formulated to help in boosting memory power and reducing stress in the body. As a person gets older, the brain cognitive tends to decline. A busy lifestyle with little rest can also cause the brain to lose its power hence causing frequent memory losses, irritability, stress, anxiety and other symptoms.

Memorall contains a blend of vitamins and herbs which promise to boost the overall memory of the user. It helps the user function in optimum capacity. The formula nourishes neurological pathways and restores mineral balance in the brain. The product is available in bottles of 60 capsules each. The product is only available through selected licensed health care professionals at a disclosable price when you place an order.

Who is the Manufacturer of Memorall?

Memorall

Memorall is manufactured by Xymogen. The company is based in the USA and it practices good manufacturing practices (GMP). The product is designed to help improve memory and concentration in people with cognitive decline.

The formula has been thoroughly researched on for years to ensure that it meets all the required quality standards. The product is safe for human consumption. It does not contain gluten, dairy products, soy or any artificial additives. It has an official website that provides further information about the product.

How Does Memorall Work?

Memorall contains a blend of natural herbs and vitamins which formulate a powerful formula that nourishes the brain cells. It nourishes the various neurological pathways naturally. It restores the balance between oxidation and cytokine release. It also restores the endocrine balance and supports mitochondrial function which releases extra energy to the brain.

It protects the neurotransmitter acetylcholine from breaking down. This maintains the normal brain wave. The supplement increases blood flow to the brain. This enables more oxygen and nutrients to be transported to the brain. This, in turn, improves brain health and improves memory.

Memorall Ingredients – Are they Safe & Effective?

Vitamin B6

  • It maintains a healthy brain function

Folate

  • It nourishes the brain to maintain a healthy brain function.

Vitamin B12

  • It nourishes the brain and improves cognitive

Acetyl-L-Carnitine

  • It supports mitochondrial oxidation of fatty acids to provide the brain with energy
  • It support healthy cognition

N-Acetyl-L-Cysteine

  • It fights oxidative stress and reduces oxidative stress
  • It maintains healthy nerve tissue

Ginkgo Biloba Extract

  • It supports memory health as well as brain health
  • It alleviates stress
  • It supports and maintains neural health

Bacopa Extract

  • It improves cognitive
  • It relieves stress from the mind
  • It neutralizes free radicals which can cause brain damage
  • It maintains brain health

Phosphatidylserine

  • It maintains the health of the cell membranes of the brain
  • It regulates the release of acetylcholine, dopamine and noradrenaline for healthy neural function

Vinpocetine

  • It maintains the health of the brain
  • It helps improve memory
  • It improves cellular metabolism and improves blood flow to the bran

Huperzine A

  • It supports a healthy learning and memory
  • It regulates the level of acetylcholine in the brain
  • It improves brain cognitive

What are the Advantages of Memorall?

  • May improve the intelligence level of the user.
  • It improves the learning capability of the user.
  • It may improve brain power.
  • It promotes cognitive.
  • It may enhance the focus and concentration.

What are the Disadvantages of Memorall?

  • The product cannot be used by minors
  • The product has not been approved by the FDA

How Should You Take Memorall?

Take one capsule twice daily or as directed by the doctor

Precautions

  • Keep tightly closed in a cool, dry place
  • Store away from children.
  • The product is not intended to prevent or cure any diseases
  • Do not use if pregnant or breast feeding
  • Do not accept if the seal is open

The Side Effects of Memorall

The manufacturer claims that the product has no side effects. However, some users have reported mild side effects. Consult a doctor in case of any severe effects

Does Memorall interact with other medication?

It is advisable to consult a doctor before supplementing on the product. Those taking blood thinners, have undergone surgery recently or suffer from high blood pressure should seek medical advice first

*All individuals are unique. Your results can and will vary.

Know The Related Products

    is a brain enhancement supplement designed to promote mental performance, improve attention and learning abilities. The effects of this dietary formula include the improved rate of grasping new information, improved memory retention, improved mental clarity, reduced stress, and improved attention span. is a dietary supplement designed to enhance brain functions. Mandookparni is one of the ingredients in this formula that work to improve mental capacity and concentration. It is also formulated with Shankhpushpi; a substance that is overcomes mental fatigue and normalizes neuro-metabolism. There is also Jatamansi an ingredient that improves intellect and is known to check CNS irritability. is a dietary supplement formulated to support brain health and optimize brain function. Said to be the real-life version of the Limitless pill, it claims to improve cognitive function, memory, and recall of information, as well as promote mental clarity, focus, and alertness. is a brain enhancement formula that is meant to improve memory, learning abilities, cognition and stress for people in need of it. The manufacturer claims that this supplement offers your body the most advanced ingredients that provide your body with nutritive support for mental performance, improved memory.

Memorall Review – Final Verdict

Memorall is one of the few brain supplements which promise to maintain the health of your brain. It contains a blend of natural ingredients which can help in treating problems related to the brain. The product is manufactured under the highest conditions and it comes with mild side effects.

The product will boost your memory power, make you more alert, improve mental clarity, focus and increase your intelligence levels in a safe and natural way. The product promises to regenerate your brain cells that have been damaged due to a busy and stressful lifestyle. Memorall is packaged in the form of easy to swallow capsules and the dosage instructions are very easy to comply with. Boost your brain power today buy buying Memorall which will definitely unlock the potential of your brain.

More than ever people of all ages are struggling with memory problems. People are unable to disconnect from their work, while students are under immense pressure to perform. Brains are overloaded with information that must be remembered. A quality memory enhancement product might contain clinically proven ingredients that will help to enhance not only memory, but also focus and night concentration. Memory products might help to optimize overall mental health and brain function.

Below you’ll find some of the most effective memory products on the market today, in our opinion.

Rating

Verdict on Claimed Benefits: Below is our summary of the available evidence for the claimed benefits of below mentioned brain health supplements and nootropic based on the available research:

Memorall Capsules 30’S

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Table of Contents Introduction:Nutritional Value of Ajwain:Potential Uses of Ajwain:Benefits of Ajwain:Side Effects of Ajwain:Precautions to Take With Ajwain:Frequently Asked Questions:References: Introduction: Ajvain (Carum copticum), also called bishops weed, is a herb that is used as a spice and a major ingredient in different types of medicines. Ajvain is thought to have originated in Egypt

Table of Contents Introduction:Nutritional Value of Papaya:Therapeutic Uses of Papaya:Benefits of Papaya:How to Use Papaya?Side Effects of Papaya: Precautions to Take With Papaya: Interactions With Other Drugs:Frequently Asked Questions:References: Introduction: Carica papaya L. (papaya) is a tropical and subtropical plant native to Mexico and northern South America that has become naturalised in many parts of

Table of Contents IntroductionChemical Constituents of Tea TreePotential Uses of Tea treeBenefits of Tea TreeHow to Use Tea Tree?Side Effects of Tea TreePrecautions to Take With Tea TreeFrequently Asked QuestionsReferences Introduction Tea tree is the name of a plant native to Australia, scientifically known as Melaleuca alternifolia.1 The oil extracted from the leaves of the

Table of Contents Introduction:Nutritional Value of Tulsi:Potential Uses of Tulsi:Benefits of Tulsi:How to Use Tulsi?Side Effects of Tulsi:Interactions With Other Drugs:Frequently Asked Questions:References: Introduction: Tulsi (Ocimum sanctum Linn) is a plant that belongs to the genus Ocimum and is known for its wide therapeutic properties. Tulsi (Hindi) is known as ‘holy basil’ in English. Tulsi

Table of Contents IntroductionNutritional ValuePotential Uses of ReethaBenefits of ReethaHow to Use Reetha?Precautions to Take With ReethaFrequently Asked QuestionsReferences Introduction Reetha, scientifically known as Sapindus mukorossi, is a large deciduous tree of the Sapindaceae family. It is commonly known by many names like soapberry, soapnut, washnut, aritha, dodan, and dodani. In countries like Japan and

Table of Contents Introduction:Nutritional Value of Olive Oil:Properties of Olive oil:Potential Uses of Olive Oil:How to Use Olive Oil?Side EffectsPrecautions to Take With Olive Oil: Interactions With Other Drugs:Frequently Asked Questions:References: Introduction: Olive (Olea europaea L.) is a small tree native to tropical and mildly temperate regions of the world that belongs to the Oleaceae

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